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An organ-on-a-chip investigation into dose-dependent, temporal dynamic effects of radiosurgery on the blood-brain barrier and its immunological response.

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第一作者： Adam D,Yock

第一单位： Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA. Electronic address: adam.d.yock@vumc.org.

作者： Adam D,Yock ^[1] ; Jacquelyn A,Brown ^[2] ; John,Eley ^[3] ; Cara,Lwin ^[4] ; Dandan,Liu ^[5] ; John P,Wikswo ^[6]

作者单位： Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA. Electronic address: adam.d.yock@vumc.org. ^[1] Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA; Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN, USA. Electronic address: JAB890@pitt.edu. ^[2] Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA. Electronic address: john.g.eley@vanderbilt.edu. ^[3] Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: cara.lwin@vumc.org. ^[4] Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: dandan.liu@vumc.org. ^[5] Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA; Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. Electronic address: john.p.wikswo@vanderbilt.edu. ^[6]

关键词 Barrier permeability Blood-brain barrier Immuno-radiotherapy Inflammatory cytokine activation Neurovascular unit Organ-on-a-chip Stereotactic radiosurgery