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Nanosensitizer for enhanced radiotherapy via tumor microenvironment reshaping and ROS amplification.

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第一作者： Junchao,Qian

第一单位： Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, P.R. China.;Department of Radiation Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui, 230031, P.R. China.;Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, P.R. China.

作者： Junchao,Qian ^[1] ; Yijun,Lu ^[2] ; Dandan,Wang ^[3] ; Shichuan,Zhong ^[4] ; Xiao,Liu ^[3] ; Xin,Lai ^[3] ; Ziwen,Wei ^[2] ; Guangyu,Ju ^[3] ; Jinying,Yang ^[5] ; Zimeng,Wang ^[3] ; Kaiwei,Wang ^[3] ; Yue,Li ^[6] ; Hongcang,Gu ^[3] ; Jian,You ^[7] ; Shuanghu,Yuan ^[8]

作者单位： Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, P.R. China.;Department of Radiation Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui, 230031, P.R. China.;Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, P.R. China. ^[1] Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, P.R. China.;Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, P.R. China. ^[2] Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, P.R. China. ^[3] Key Lab of Materials Physics, Anhui Key Lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, P. R. China. ^[4] Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, P.R. China. ^[5] Key Lab of Materials Physics, Anhui Key Lab of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230031, P. R. China.;Tiangong University, Tianjin 300387, P. R. China. ^[6] College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang, 310058, P. R. China. ^[7] Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, P.R. China.;Department of Radiation Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui, 230031, P.R. China. ^[8]

关键词 MR-CT dual-modal imaging ROS amplification gold@manganese dioxide core-shell nanoparticles hypoxia alleviation radiotherapy