首页> The Journal of clinical endocrinology and metabolism> Secukinumab in Moderate-to-Severe Graves Orbitopathy: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study.

Secukinumab in Moderate-to-Severe Graves Orbitopathy: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study.

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第一作者： Jan,Wolf

第一单位： Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz 55101, Germany.

作者： Jan,Wolf ^[1] ; Katrin,Lorenz ^[2] ; Ahmed E,Othman ^[3] ; Anna,Beck ^[2] ; Helena M,Michel ^[2] ; Lea,Grauhan ^[2] ; Heike,Elflein ^[2] ; Maximilian,Luffy ^[1] ; Anja,Eckstein ^[4] ; Harald,Lahner ^[5] ; Michael,Schittkowski ^[6] ; Maren,Horn ^[6] ; Wolf A,Lagrèze ^[7] ; Tim,Bleul ^[7] ; Susanne,Pitz ^[8] ; Christian,Vorländer ^[9] ; Christelle C,Pieterse ^[10] ; Brian,Porter ^[11] ; Andreas,Clemens ^[12] ; Steven,Draikiwicz ^[11] ; Maximilian,Reinhardt ^[10] ; George J,Kahaly ^[1]

作者单位： Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz 55101, Germany. ^[1] Department of Ophthalmology, JGU Medical Center, Mainz 55101, Germany. ^[2] Department of Neuroradiology, JGU Medical Center, Mainz 55101, Germany. ^[3] Clinic for Ophthalmology, University Clinic Essen, Essen 45147, Germany. ^[4] Clinic for Endocrinology, Diabetology and Metabolism, University Clinic Essen, Essen 45147, Germany. ^[5] Department of Ophthalmology, University Medicine Göttingen, Göttingen D 37085, Germany. ^[6] Interdisciplinary Center for Orbital Diseases, Department of Neuroophthalmlogy, Eye Center, Medical Center, Medical Faculty, University Freiburg, Freiburg 79106, Germany. ^[7] Orbital Center, Department of Ophthalmology, Bürgerhospital, Frankfurt 60318, Germany. ^[8] Clinic for Endocrine Surgery, Bürgerhospital, Frankfurt 60318, Germany. ^[9] Global Medical Affairs, Immunology, Novartis Pharma AG, Basel 4056, Switzerland. ^[10] Clinical Development, Immunology, Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936-1080, USA. ^[11] Department of Medicine I, Johannes Gutenberg University (JGU) Medical Center, Mainz 55101, Germany.;Global Medical Affairs, Immunology, Novartis Pharma AG, Basel 4056, Switzerland. ^[12]

关键词 Graves orbitopathy ORBIT trial active immunosuppressive treatment interleukin-17A moderate-to-severe GO secukinumab