换一批Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus.
第一作者：
Nick M A,Shubert
第一单位：
Department of Otorhinolaryngology / Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands, 9700 RB Groningen, The Netherlands.
作者：
Nick M A,Shubert [1]
;
Shuyang,Yao [2]
;
Maryam Kazemi,Naeini [3]
;
Natalia,Trpchevska [4]
;
Charles,Bishop [5]
;
Argyro,Bizaki-Vallaskangas [6]
;
Linda,Broer [7]
;
Fabio,Castellana [8]
;
Kaare,Christensen [9]
;
Jacob V B,Hjelmborg [10]
;
Maria Pina,Concas [11]
;
Aurora,Santin [12]
;
Giorgia,Girotto [12]
;
Giuseppe Giovanni,Nardone [13]
;
Licia,Iacoviello [14]
;
Estonian Biobank Research Team [15]
;
Jonas,Mengel-From [16]
;
Scott,Gallagher [17]
;
Alexander,Gudjonsson [18]
;
Vilmundur,Gudnason [19]
;
Nancy L,Heard-Costa [20]
;
Sudha,Seshadri [21]
;
Howard J,Hoffman [21]
;
Chuan-Ming,Li [22]
;
Jaakko,Kaprio [22]
;
Joel,Rämö [22]
;
Elmo,Saarentaus [23]
;
Johannes,Kettunen [24]
;
Kristi,Krebs [2]
;
Anna K,Kähler [25]
;
Lenore J,Launer [26]
;
Hampton,Leonard [26]
;
Mike A,Nalls [2]
;
Patrik K E,Magnusson [7]
;
Joyce,van Meurs [24]
;
Lili,Milani [27]
;
Antti,Mäkitie [28]
;
Berthe C,Oosterloo [15]
;
Marianne,Nygaard [22]
;
Teemu,Palviainen [29]
;
Sheila,Pratt [30]
;
Nicola,Quaranta [8]
;
Rodolfo,Sardone [20]
;
Claudia L,Satizabal [5]
;
John M,Schweinfurth [31]
;
Eric,Shiroma [32]
;
Eleanor,Simonsick [5]
;
Lifelines Cohort Study [33]
;
Christopher,Spankovich [28]
;
Patrick F,Sullivan [28]
;
Andre,Goedegebure [34]
;
Andries Paul,Nagtegaal [35]
;
Sonja J,Pyott [3]
;
Christopher R,Cederroth [3]
;
Maxim B,Freidin ;
Frances Mk,Williams
作者单位：
Department of Otorhinolaryngology / Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands, 9700 RB Groningen, The Netherlands.
[1]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
[2]
Department of Twin Research and Genetic Epidemiology, School of Life Course and Population Sciences, King's College London, London, UK.
[3]
Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
[4]
Department of Otolaryngology and Communicative Sciences, The University of Mississippi Medical Center, Jackson, MS 39216, USA.
[5]
Tampere University, Faculty of Medicine and Health Technology, Department of Otolaryngology, Tampere, Finland.;Pirkanmaan hyvinvointialue, Department of Ear and Oral Diseases, Tampere, Finland.
[6]
Department of Internal Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.
[7]
Unit of Epidemiology and Statistics, Local Health Authority of Taranto, Taranto, Italy.
[8]
The Danish Twin Registry, Department of Public Health, University of Southern Denmark, 5000 Odense C, Denmark.;Department of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark.;Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, 5000 Odense C, Denmark.
[9]
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, 5000 Odense C, Denmark.
[10]
Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, 34127 Trieste, Italy.
[11]
Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, 34127 Trieste, Italy.;Department of Medicine Surgery and Health Sciences, University of Trieste, Trieste Italy.
[12]
Department of Medicine Surgery and Health Sciences, University of Trieste, Trieste Italy.
[13]
Department of Epidemiology and Prevention, I.R.C.C.S. Neuromed, Pozzilli, Italy.;Department of Medicine and Surgery, LUM University, Casamassima, Italy.
[14]
The Danish Twin Registry, Department of Public Health, University of Southern Denmark, 5000 Odense C, Denmark.;Department of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark.
[15]
Decibel Therapeutics Inc.
[16]
Icelandic Heart Association, 201 Kopavogur, Iceland.
[17]
Icelandic Heart Association, 201 Kopavogur, Iceland.;Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
[18]
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.;Framingham Heart Study, Framingham, MA 01702, USA.
[19]
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.;Framingham Heart Study, Framingham, MA 01702, USA.;Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases and Department of Population Health Sciences, University of Texas Health Sciences Center, San Antonio, TX 78229, USA.
[20]
Epidemiology, Statistics, and Population Sciences, National Institute on Deafness and Other Communications Disorders (NIDCD), NIH, Bethesda, MD 20892, USA.
[21]
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
[22]
Systems medicine, Research unit of Population Health, University of Oulu, 90220 Oulu, Finland.;Biocenter Oulu, University of Oulu, 90220 Oulu, Finland.;Finnish Institute for Health and Welfare, 00271 Helsinki, Finland.
[23]
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
[24]
Laboratory of Epidemiology and Population Sciences, Intramural Research Program National Institute on Aging, Bethesda, MD 20892, USA.
[25]
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.;Center for Alzheimer's and Related Dementias, Bethesda, MD 20892, USA.;Data Tecnica, Washington DC, 20037, USA.
[26]
Department of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, 00029 HUS, Helsinki, Finland.
[27]
Department of Otorhinolaryngology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.
[28]
Department of Communication Science & Disorders, University of Pittsburgh, Pittsburgh, Pa 15260, USA.
[29]
Otolaryngology Unit, Department of Translational Biomedicine and Neuroscience (DiBrain), University of Bari, Policlinico di Bari, Italy.
[30]
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD 21224, USA.
[31]
Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
[32]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.;Department of Genetics, University of North Carolina, Chapel Hill, NC 27516, USA.
[33]
Department of Otorhinolaryngology / Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands, 9700 RB Groningen, The Netherlands.;Department of Neuroscience, School of Medicine and Health Science, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.
[34]
Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.;Department of Otolaryngology, Head & Neck Surgery, University of Tübingen Medical Center, 72076 Tübingen, Germany.
[35]
DOI
10.1101/2025.11.28.25340151
PMID
41378354
发布时间
2025-12-23
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medRxiv
medRxiv
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