首页> mAbs> Fine-tuning affinity and spacer design enhances T cell potency in DLL3 and BCMA CAR T cells.

Fine-tuning affinity and spacer design enhances T cell potency in DLL3 and BCMA CAR T cells.

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第一作者： Nicholas,Mazzanti

第一单位： Therapeutics Discovery, Johnson & Johnson Innovative Medicine, Spring House, PA, USA.;School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA.

作者： Nicholas,Mazzanti ^[1] ; Ninkka,Tamot ^[2] ; Andrea,Francese ^[2] ; Jinquan,Luo ^[2] ; M Jack,Borrok ^[3] ; Julie,Rossillo ^[2] ; Joseph,Plummer ^[2] ; Gauri Anand,Patwardhan ^[2] ; Chi Shing,Sum ^[2] ; Michael,Ports ^[4] ; Kara L,Spiller ^[5] ; Madhusudhanan,Sukumar ^[2]

作者单位： Therapeutics Discovery, Johnson & Johnson Innovative Medicine, Spring House, PA, USA.;School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA. ^[1] Therapeutics Discovery, Johnson & Johnson Innovative Medicine, Spring House, PA, USA. ^[2] Protein Engineering, Amgen Inc, Thousand Oaks, CA, USA. ^[3] Cell Therapy, CARGO Therapeutics Inc, San Carlos, CA, USA. ^[4] School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA. ^[5]

关键词 Affinity CAR CAR design chimeric antigen receptor spacer domain

医学主题词人类(Humans);B细胞成熟抗原(B-Cell Maturation Antigen);免疫疗法, 过继(Immunotherapy, Adoptive);膜蛋白质类(Membrane Proteins);T淋巴细胞(T-Lymphocytes);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);细胞系, 肿瘤(Cell Line, Tumor)

DOI 10.1080/19420862.2025.2602989

PMID 41383027

发布时间 2026-04-30

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