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A fully iPS-cell-derived 3D model of the human blood-brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions.

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第一作者: Judit,González-Gallego
第一单位: Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.;Graduate School of Systemic Neuroscience (GSN), LMU Munich, Munich, Germany.
作者单位: Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.;Graduate School of Systemic Neuroscience (GSN), LMU Munich, Munich, Germany. [1] Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany. [2] German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.;Neuroproteomics, School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. [3] Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.;Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center Munich, Neuherberg, Germany. [4] German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. [5] Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany. [6] Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany.;Deep Piction, Munich, Germany.;School of Medicine, Koç University, Istanbul, Turkey. [7] Department of Pharmacology, University of Vermont, Burlington, VT, USA.;Division of Cardiovascular Sciences, University of Manchester, Manchester, UK. [8] German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany. [9] German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.;Neuroproteomics, School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. [10] Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany. Martin.Dichgans@med.uni-muenchen.de.;Graduate School of Systemic Neuroscience (GSN), LMU Munich, Munich, Germany. Martin.Dichgans@med.uni-muenchen.de.;German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany. Martin.Dichgans@med.uni-muenchen.de.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Martin.Dichgans@med.uni-muenchen.de.;German Centre for Cardiovascular Research (DZHK), Munich, Germany. Martin.Dichgans@med.uni-muenchen.de. [11] Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany. dominik.paquet@med.uni-muenchen.de.;Graduate School of Systemic Neuroscience (GSN), LMU Munich, Munich, Germany. dominik.paquet@med.uni-muenchen.de.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. dominik.paquet@med.uni-muenchen.de. [12]
DOI 10.1038/s41593-025-02123-w
PMID 41398476
发布时间 2026-02-10
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