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HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion.

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第一作者: Yoav,Chemla
第一单位: Department of Human Genetics and Biochemistry, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
作者单位: Department of Human Genetics and Biochemistry, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel. [1] Department of Human Genetics and Biochemistry, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel; Ella Lemelbaum Institute for Immuno-Oncology and Melanoma, Sheba Medical Center, Ramat Gan 52621, Israel. [2] Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. [3] Department of Pathology, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel. [4] Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. [5] Ella Lemelbaum Institute for Immuno-Oncology and Melanoma, Sheba Medical Center, Ramat Gan 52621, Israel. [6] Department of Dermatology, Sheba Medical Center, Ramat Gan, Israel. [7] Laboratory of Cancer Stemness, GIGA Institute, University of Liège, Liège, Belgium. [8] Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. [9] Department of Clinical Microbiology and Immunology, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. [10] Single Cell Genomics Core, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. [11] Biomedical Core Facility, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. [12] Smoler Proteomics Center, Lokey Interdisciplinary Center for Life Sciences & Engineering, Technion-Israel Institute of Technology, Haifa, Israel. [13] Blavatnik School of Computer Science and Artificial Intelligence, Tel Aviv University, Tel Aviv, Israel. [14] Institute of Oncology, E. Wolfson Medical Center, Holon, Israel. [15] Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA. [16] Department of Molecular Cell Biology, Weizmann Institute of Science, Tel Aviv, Israel. [17] Institute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. [18] Metabolic Center, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel. [19] Bio-Imaging Unit, Hebrew University, Jerusalem 91904, Israel. [20] Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel. [21] Hadassah Cancer Research Institute, Hadassah Hebrew University Hospital, Jerusalem, Israel. [22] Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel; The School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel. [23] School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel. [24] Ella Lemelbaum Institute for Immuno-Oncology and Melanoma, Sheba Medical Center, Ramat Gan 52621, Israel; Department of Clinical Microbiology and Immunology, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel; Samueli Integrative Pioneering Institute and Davidoff Center, Rabin Medical Center, Petach Tikva, Israel; Felsenstein Cancer Research Center, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. [25] Gustave Roussy Cancer Campus, INSERM U1015, Universite Paris-Saclay, 114 rue Edouard Vaillant, 94800 Villejuif, France. Electronic address: mehdi.khaled@gustaveroussy.fr. [26] Laboratory of Cancer Signaling, GIGA Institute, University of Liège, Liège, Belgium. Electronic address: pierre.close@uliege.be. [27] Ella Lemelbaum Institute for Immuno-Oncology and Melanoma, Sheba Medical Center, Ramat Gan 52621, Israel. Electronic address: ronnie.shapira@sheba.health.gov.il. [28] Gustave Roussy Cancer Campus, INSERM U1015, Universite Paris-Saclay, 114 rue Edouard Vaillant, 94800 Villejuif, France. Electronic address: sebastien.apcher@gustaveroussy.fr. [29] Department of Pathology, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: asafmadi@tauex.tau.ac.il. [30] University of Zurich, Faculty of Medicine, University Hospital of Zurich, Department of Dermatology, Schlieren 8952, Switzerland. Electronic address: mitchell.levesque@usz.ch. [31] Laboratory of Cancer Stemness, GIGA Institute, University of Liège, Liège, Belgium. Electronic address: francesca.rapino@uliege.be. [32] Department of Pathology, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: yaroncarmi@gmail.com. [33] Department of Human Genetics and Biochemistry, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel; Ragon Institute of Mass General, MIT and Harvard, Cambridge, MA, USA. Electronic address: ssparikh@mgh.harvard.edu. [34] Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Electronic address: yardena.samuels@weizmann.ac.il. [35] Department of Human Genetics and Biochemistry, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: carmitlevy@tauex.tau.ac.il. [36]
DOI 10.1016/j.cell.2025.11.020
PMID 41401806
发布时间 2026-04-09
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Cell

2026年189卷1期

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