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Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity.

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第一作者： Yi,Jin

第一单位： Department of Epidemiology, Second Military Medical University, Shanghai 200433, China; Key Laboratory of Biological Defense, Ministry of Education, Second Military Medical University, Shanghai 200433, China; Shanghai Key Laboratory of Medical Bioprotection, Second Military Medical University, Shanghai 200433, China.

作者： Yi,Jin ^[1] ; Zhiyu,Yang ^[2] ; Zishuai,Li ^[1] ; Zhan,Ding ^[1] ; Xueyi,Zhang ^[1] ; Huixian,Zeng ^[2] ; Letian,Fang ^[1] ; Yiwei,Shi ^[1] ; Puyi,Xing ^[2] ; Wenbin,Liu ^[1] ; Hongsen,Chen ^[1] ; Chunxia,Jing ^[3] ; Guangwen,Cao ^[4]

作者单位： Department of Epidemiology, Second Military Medical University, Shanghai 200433, China; Key Laboratory of Biological Defense, Ministry of Education, Second Military Medical University, Shanghai 200433, China; Shanghai Key Laboratory of Medical Bioprotection, Second Military Medical University, Shanghai 200433, China. ^[1] Department of Epidemiology, Second Military Medical University, Shanghai 200433, China; Key Laboratory of Biological Defense, Ministry of Education, Second Military Medical University, Shanghai 200433, China; Shanghai Key Laboratory of Medical Bioprotection, Second Military Medical University, Shanghai 200433, China; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China. ^[2] Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China. ^[3] Department of Epidemiology, Second Military Medical University, Shanghai 200433, China; Key Laboratory of Biological Defense, Ministry of Education, Second Military Medical University, Shanghai 200433, China; Shanghai Key Laboratory of Medical Bioprotection, Second Military Medical University, Shanghai 200433, China. Electronic address: gcao@smmu.edu.cn. ^[4]

关键词 aerobic exercise training bulk RNA sequencing cancer cohort study immunosenescence overall immunity physical activity single-cell RNA sequencing systemic inflammation

医学主题词运动(Exercise)(Exercise);动物(Animals);人类(Humans);炎症(Inflammation);肿瘤(Neoplasms);小鼠(Mice);男(雄)性(Male);女(雌)性(Female);中年人(Middle Aged);老年人(Aged);成年人(Adult)

DOI 10.1016/j.xcrm.2025.102484

PMID 41406938

发布时间 2026-01-08

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2025年6卷12期

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