首页> Communications biology> TRIM21 promotes K63-linked ubiquitination of ALKBH5 and suppresses cuproptosis via down-regulation of LIAS in esophageal squamous cell carcinoma.

TRIM21 promotes K63-linked ubiquitination of ALKBH5 and suppresses cuproptosis via down-regulation of LIAS in esophageal squamous cell carcinoma.

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第一作者： Anqi,Feng

第一单位： Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.

作者： Anqi,Feng ^[1] ; Lingnan,He ^[1] ; Zhaoxing,Li ^[1] ; Zeyu,Wang ^[1] ; Mingchuang,Sun ^[1] ; Ziying,Zhao ^[1] ; Zehua,Zhang ^[1] ; Kang,Fang ^[1] ; Hao,Wu ^[1] ; Xiaoyuan,Wang ^[1] ; Shihan,Zhang ^[1] ; Zhukai,Chen ^[1] ; Li,Zhang ^[2] ; Tao,Chen ^[3] ; Meidong,Xu ^[4]

作者单位： Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. ^[1] Department of Pathology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. ^[2] Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. chentao@tongji.edu.cn. ^[3] Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. 1800512@tongji.edu.cn. ^[4]

医学主题词人类(Humans);泛素化(Ubiquitination);核糖核蛋白类(Ribonucleoproteins);食管肿瘤(Esophageal Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);减量调节(Down-Regulation);动物(Animals);小鼠(Mice);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic)

DOI 10.1038/s42003-025-09201-6

PMID 41413718

发布时间 2025-12-21

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Communications biology

2025年8卷1期

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Communications biology

2025年8卷1期

1783页

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TRIM21 promotes K63-linked ubiquitination of ALKBH5 and suppresses cuproptosis via down-regulation of LIAS in esophageal squamous cell carcinoma.

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TRIM21 promotes K63-linked ubiquitination of ALKBH5 and suppresses cuproptosis via down-regulation of LIAS in esophageal squamous cell carcinoma.

Communications biology

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Communications biology

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