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Engineering with care: safety assessment platforms for CRISPR-modified natural killer cells.

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第一作者： Alieh,Fazeli

第一单位： Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany.;PhD Program, Faculty of Biology, University of Freiburg, Freiburg, Germany.

作者： Alieh,Fazeli ^[1] ; Evelyn,Ullrich ^[2] ; Toni,Cathomen ^[3] ; Tobias,Bexte ^[4]

作者单位： Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany.;PhD Program, Faculty of Biology, University of Freiburg, Freiburg, Germany. ^[1] Department of Pediatrics, Experimental Immunology and Cell Therapy, Goethe University Frankfurt, Frankfurt am Main, Germany.;Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt am Main, Germany.;German Cancer Consortium (DKTK) partner site Frankfurt/Mainz, Frankfurt am Main, Germany. ^[2] Institute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany.;Center for Cell and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany.;German Cancer Consortium (DKTK) partner site Freiburg, Freiburg, Germany.;Faculty of Medicine, University of Freiburg, Freiburg, Germany. ^[3] Department of Pediatrics, Experimental Immunology and Cell Therapy, Goethe University Frankfurt, Frankfurt am Main, Germany.;German Cancer Consortium (DKTK) partner site Frankfurt/Mainz, Frankfurt am Main, Germany.;German Red Cross Blood Service Baden-Württemberg - Hessen, Institute for Transfusion Medicine and Immunohematology, Frankfurt am Main, Germany.;Berlin Center for Advanced Therapies, Charité - Universitätsmedizin Berlin, Berlin, Germany. ^[4]

关键词 CRISPR NK cells allogenic cell therapy gene-editing off-target safety assessment

医学主题词杀伤细胞, 天然(Killer Cells, Natural);人类(Humans);动物(Animals);免疫疗法, 过继(Immunotherapy, Adoptive)

DOI 10.3389/fimmu.2025.1711414

PMID 41425600

发布时间 2025-12-24

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准确一般字义偏差语意偏离译文作用小提交