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The Alzheimer's disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states.

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第一作者： Dalya,Rosner

第一单位： Alector, Inc., South San Francisco, CA 94080, USA. Electronic address: dalya.rosner@gmail.com.

作者： Dalya,Rosner ^[1] ; Jiahong,Sun ^[2] ; Rita,Cacace ^[3] ; Angie,Yee ^[2] ; Chaitanya,Wagh ^[2] ; Anna,Rychkova ^[2] ; Mariah,Dunlap ^[2] ; Daniel,Gulbranson ^[2] ; Adiljan,Ibrahim ^[2] ; Xiaoting,Wang ^[2] ; Rebecca,Wang ^[2] ; Alice,Buonfiglioli ^[4] ; Muhammad,Alhawagri ^[2] ; Phil,Kong ^[2] ; Marina,Roell ^[2] ; Wei-Hsien,Ho ^[2] ; Belvin,Gong ^[2] ; Heidi,Denton ^[3] ; Giacomo,Muscarnera ^[3] ; Tim,Meese ^[3] ; Malak,El-Khatib ^[2] ; Daniel,Bermingham ^[2] ; Elias,Kahn ^[2] ; Francesca,Cignarella ^[2] ; Herve,Rhinn ^[2] ; Zia,Khan ^[2] ; Tina,Schwabe ^[2] ; Karpagam,Srinivisan ^[2] ; Ananya,Mitra ^[2] ; Lotje,de Witte ^[4] ; Peter,Heutink ^[2] ; Renzo,Mancuso ^[3] ; Ilaria,Tassi ^[2] ; Julia,Kuhn ^[2] ; Hua,Long ^[2] ; Sara,Kenkare-Mitra ^[2] ; Arnon,Rosenthal ^[2]

作者单位： Alector, Inc., South San Francisco, CA 94080, USA. Electronic address: dalya.rosner@gmail.com. ^[1] Alector, Inc., South San Francisco, CA 94080, USA. ^[2] Laboratory of Microglia and Inflammation in Neurological Disorders (MIND), VIB-Center for Molecular Neurology (CMN), VIB, Universiteit Antwerpen-CDE, Antwerpen, Belgium. ^[3] Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[4]

关键词 Alzheimer’s disease DAP12 MS4A MS4A4A MS4A6A TREM2 TYROBP macrophage microglia neurodegeneration