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Advanced Human Immune Cell-Organoid Co-Cultures for Functional Testing of Cancer Nanovaccines.

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第一作者： Nathalia,Ferreira

第一单位： Translational Molecular Imaging, Max-Planck-Institute For Multidisciplinary Sciences, Göttingen, Germany.

作者： Nathalia,Ferreira ^[1] ; David,Agorku ^[2] ; Andre,Rosa ^[3] ; Julia,Roosz ^[3] ; Lena,Christ ^[3] ; Nicole,Anderle ^[3] ; Ajinkya,Kulkarni ^[1] ; Abir,Hussein ^[4] ; Sana S,Sayedipour ^[5] ; Omar F,Luna ^[6] ; Tobias,Legler ^[7] ; Philipp,Ströbel ^[8] ; Fernando,Albericio ^[6] ; Luis,Cruz ^[5] ; Phillipp,Beckhove ^[9] ; Peter,Loskill ^[10] ; Frauke,Alves ^[11] ; M Andrea,Markus ^[1] ; Fernanda,Ramos-Gomes ^[1]

作者单位： Translational Molecular Imaging, Max-Planck-Institute For Multidisciplinary Sciences, Göttingen, Germany. ^[1] Miltenyi Biotec B.V. & Co. KG, Bergisch Gladbach, Germany. ^[2] NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany. ^[3] Division of Interventional Immunology, Leibniz Institute for Immunotherapy, Regensburg, Germany. ^[4] Department of Radiology, Leiden University Medical Center, Leiden, Netherlands. ^[5] Department of Organic Chemistry, University of Barcelona, and CIBER-BBN, Networking Centre on Bioengineering, Biomaterials, and Nanomedicine, Barcelona, Spain. ^[6] Department of Transfusion Medicine, University Medical Center Göttingen, Göttingen, Germany. ^[7] Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany. ^[8] Division of Interventional Immunology, Leibniz Institute for Immunotherapy, Regensburg, Germany.;Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany. ^[9] NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.;Department of Microphysiological Systems, Institute of Biomedical Engineering, Faculty of Medicine, Eberhard Karls University-Tübingen, Tübingen, Germany.;3R Center Tübingen for In Vitro Models and Alternatives to Animal Testing, Tübingen, Germany. ^[10] Translational Molecular Imaging, Max-Planck-Institute For Multidisciplinary Sciences, Göttingen, Germany.;Clinic of Hematology and Medical Oncology and Department of Diagnostic and Interventional Radiology, University Medical Center Göttingen, Göttingen, Germany. ^[11]

关键词 PDAC cancer vaccine immunotherapy mesothelin organoids

医学主题词人类(Humans);共同培养技术(Coculture Techniques);类器官(Organoids);癌, 胰腺管(Carcinoma, Pancreatic Ductal);癌症疫苗(Cancer Vaccines);胰腺肿瘤(Pancreatic Neoplasms);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);氟尿嘧啶(Fluorouracil);T淋巴细胞(T-Lymphocytes);免疫疗法(Immunotherapy);醛氢叶酸(Leucovorin)

DOI 10.1002/advs.202515199

PMID 41436389

发布时间 2026-02-20

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2026年13卷10期

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Advanced Human Immune Cell-Organoid Co-Cultures for Functional Testing of Cancer Nanovaccines.

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Advanced Human Immune Cell-Organoid Co-Cultures for Functional Testing of Cancer Nanovaccines.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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