首页> Molecular therapy : the journal of the American Society of Gene Therapy> Lung-tropic dual AAV-SP-C and microRNA gene therapy attenuates lung injury in mutant Sftpc mice.

Lung-tropic dual AAV-SP-C and microRNA gene therapy attenuates lung injury in mutant Sftpc mice.

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第一作者： Pauline,Bardin

第一单位： Sinclair Center for Regenerative Medicine, Ottawa Hospital Research Institute (OHRI) and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.

作者： Pauline,Bardin ^[1] ; Liqun,Xu ^[1] ; Yanlong,Pei ^[2] ; Adithya Achuthan,Vineeth ^[1] ; Kennedy,Nangle ^[1] ; Shumei,Zhong ^[1] ; Chanèle,Cyr-Depauw ^[1] ; Arul,Vadivel ^[1] ; Emily,Martin ^[3] ; Timothy E,Weaver ^[3] ; Sneha,Sitaraman ^[4] ; Sarah K,Wootton ^[2] ; Bernard,Thébaud ^[5]

作者单位： Sinclair Center for Regenerative Medicine, Ottawa Hospital Research Institute (OHRI) and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada. ^[1] Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada. ^[2] Division of Pulmonary Biology, Cincinnati Children's Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. ^[3] Division of Pulmonary & Sleep Medicine, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ^[4] Sinclair Center for Regenerative Medicine, Ottawa Hospital Research Institute (OHRI) and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, Ottawa, ON, Canada. Electronic address: bthebaud@ohri.ca. ^[5]

关键词 AAV AAV6.2FF I73T mutation adeno-associated virus combinatorial therapy gene therapy inherited surfactant disorders lung-targeted gene therapy surfactant protein C deficiency