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<i>Akkermansia muciniphila</i> alleviates experimental colitis through FXR-mediated repression of unspliced XBP1.

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第一作者： Fan,Bu

第一单位： Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.;Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.;Department of Colorectal Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, China.;Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

作者： Fan,Bu ^[1] ; Kaiqing,Zhang ^[2] ; Bingbing,Song ^[2] ; Linhai,He ^[3] ; Zhihua,Lu ^[3] ; Xiaomin,Yuan ^[3] ; Chen,Chen ^[3] ; Feng,Jiang ^[3] ; Yu,Tao ^[3] ; Wei,Zhang ^[3] ; Dan,Zhang ^[3] ; Yugen,Chen ^[3] ; Qiong,Wang ^[2]

作者单位： Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.;Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.;Department of Colorectal Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, China.;Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. ^[1] Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.;Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.;No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.;Department of Basic Pharmacology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. ^[2] Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.;Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, People's Republic of China.;Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.;No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China. ^[3]

关键词 Akkermansia muciniphila endoplasmic reticulum (ER) stress farnesoid X receptor (FXR)ulcerative colitis (UC)

医学主题词动物(Animals);小鼠(Mice);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);硫酸葡聚糖(Dextran Sulfate);小鼠, 近交C57BL(Mice, Inbred C57BL);结肠炎(Colitis);男(雄)性(Male);疾病模型, 动物(Disease Models, Animal);结肠炎, 溃疡性(Colitis, Ulcerative);代谢组学(Metabolomics);结肠(Colon);有益菌种(Probiotics)

DOI 10.1128/msystems.01589-25

PMID 41459926

发布时间 2026-02-19

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<i>Akkermansia muciniphila</i> alleviates experimental colitis through FXR-mediated repression of unspliced XBP1.

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