首页> International immunopharmacology> Lactate represses MHC-I antigen presentation via H4K5 lactylation-PRC2 in small cell lung cancer subtype A.

Lactate represses MHC-I antigen presentation via H4K5 lactylation-PRC2 in small cell lung cancer subtype A.

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第一作者： Yifan,Cai

第一单位： Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Key Laboratory of Precision Radiation Oncology, Wuhan 430022, China.

作者： Yifan,Cai ^[1] ; Xinyue,Li ^[2] ; Shuang,Zhu ^[1] ; Hao,Wu ^[2] ; Jun,Nie ^[3] ; Fang,Huang ^[4]

作者单位： Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Key Laboratory of Precision Radiation Oncology, Wuhan 430022, China. ^[1] State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430022, China; Hubei Hongshan Laboratory, Wuhan 430022, China; Interdisciplinary Sciences Research Institute, Huazhong Agricultural University, Wuhan 430022, China. ^[2] Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: jun_nie@aliyun.com. ^[3] Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Key Laboratory of Precision Radiation Oncology, Wuhan 430022, China. Electronic address: proton948@126.com. ^[4]

关键词 Histone lactylation (H4K5la)Immunotherapy LDHA MHC-I antigen presentation PRC2 Small cell lung cancer subtype A (SCLC-A)