首页> Pharmaceuticals (Basel, Switzerland)> Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively.

Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively.

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第一作者： Alexia,Grangeon

第一单位： Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 St. Denis Street, Montréal, QC H2X 0A9, Canada.

作者： Alexia,Grangeon ^[1] ; Matthew L,Arwood ^[2] ; David,Thacker ^[2] ; Fleur,Gaudette ^[1] ; Jacques,Turgeon ^[3] ; Veronique,Michaud ^[4]

作者单位： Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 St. Denis Street, Montréal, QC H2X 0A9, Canada. ^[1] GalenusRx Inc., P.O. Box 560025, Montverde, FL 34756, USA. ^[2] GalenusRx Inc., P.O. Box 560025, Montverde, FL 34756, USA.;Faculty of Pharmacy, Université de Montréal, 2940 Chemin de la Polytechnique, Montréal, QC H3T 1J4, Canada. ^[3] Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 St. Denis Street, Montréal, QC H2X 0A9, Canada.;GalenusRx Inc., P.O. Box 560025, Montverde, FL 34756, USA.;Faculty of Pharmacy, Université de Montréal, 2940 Chemin de la Polytechnique, Montréal, QC H3T 1J4, Canada. ^[4]

关键词 CYP450 cryopreserved human intestinal mucosa human hepatocytes human intestinal mucosa human liver microsomes pharmacokinetic-pharmacodynamic modeling proteomics

DOI 10.3390/ph18121789

PMID 41471278

发布时间 2026-01-03

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