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Shared genetic architecture of brain age gap across 30 cohorts worldwide.

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第一作者: Vilte,Baltramonaityte
第一单位: Department of Psychology, University of Bath, Bath, United Kingdom.
作者: Vilte,Baltramonaityte [1] ; Philippe,Jawinski [2] ; Marlene,Staginnus [1] ; Mina,Shahisavandi [3] ; Boglarka Z,Kovacs [4] ; Isabel K,Schuurmans [3] ; Constantinos,Constantinides [1] ; Ahmad R,Hariri [5] ; Alexander,Teumer [6] ; Amanda L,Rodrigue [7] ; Ami,Tsuchida [8] ; Amirhossein,Manzouri [9] ; Andriana,Karuk [10] ; Anna E,Fürtjes [11] ; Annalisa,Lella [12] ; Annchen R,Knodt [5] ; Antonia,Jüllig [13] ; Avshalom,Caspi [14] ; Benedicto,Crespo-Facorro [15] ; Brenda Wjh,Penninx [16] ; Catharina,Lavebratt [17] ; Christine,Lochner [18] ; Clarissa L,Yasuda [19] ; Dag,Alnæs [20] ; Dan J,Stein [21] ; Daniel H,Mathalon [22] ; David C,Glahn [23] ; Dennis,Klose [16] ; Dylan J,Kiltschewskij [24] ; Edith,Pomarol-Clotet [10] ; Estela M,Bruxel [25] ; Fabrice,Crivello [8] ; Fernando,Cendes [26] ; Gail,Davies [27] ; Giovanni A,Salum [28] ; Hans J,Grabe [29] ; Heather J,Zar [30] ; Henning,Tiemeier [31] ; Henry,Völzke [32] ; Hervé,Lemaître [8] ; Iscia,Lopes-Cendes [25] ; Ítalo Karmann,Aventurato [26] ; Jean,Shin [33] ; Jessica A,Turner [34] ; Joanna M,Wardlaw [35] ; John,Blangero [36] ; Jonathan C,Ipser [37] ; Judith M,Ford [38] ; Kang,Sim [39] ; Karen,Sugden [5] ; Katharina,Wittfeld [40] ; Kristina,Salontaji [4] ; Kristoffer Nt,Månsson [41] ; L Elliot,Hong [42] ; Lars T,Westlye [20] ; Lianne,Schmaal [43] ; Lucas T,Ito [44] ; Lucas,Scárdua-Silva [19] ; Marcos L,Santoro [44] ; María,Alemany-Navarro [45] ; Mark E,Bastin [46] ; Mary S,Mufford [47] ; Melissa J,Green [48] ; Murray J,Cairns [24] ; Nadine,Parker [49] ; Nathaniel W,McGregor [50] ; Ole A,Andreassen [49] ; Oliver,Gruber [51] ; Oliver J,Watkeys [52] ; Pedro M,Pan [53] ; Peter,Kochunov [42] ; Qian Hui,Chew [39] ; Rafael,Romero-Garcia [54] ; Raymond,Salvador [10] ; Reremoana,Theodore [55] ; Richie,Poulton [55] ; Robin,Bülow [56] ; Rodrigo A,Bressan [57] ; Ryan L,Muetzel [58] ; Sebastian,Markett [2] ; Serena,Defina [59] ; Sheri-Michelle,Koopowitz [37] ; Shir,Dahan [60] ; Simon R,Cox [11] ; Sintia,Belangero [61] ; So M,Vijayakumar Kamalakannan [12] ; Sophia I,Thomopoulos [62] ; Stefan,Frenzel [40] ; Terrie E,Moffitt [14] ; Theo Gm,van Erp [63] ; Tomas,Furmark [64] ; Tomas,Paus [65] ; Uwe,Völker [66] ; Vince D,Calhoun [67] ; Yann,Quidé [68] ; Younghwa,Lee [51] ; Yuri,Milaneschi [69] ; Zdenka,Pausova [33] ; Paul M,Thompson [62] ; Laura Km,Han [70] ; Jean-Baptiste,Pingault [71] ; James H,Cole [72] ; Charlotte Am,Cecil [4] ; Sarah E,Medland [73] ; Danai,Dima [74] ; Esther,Walton [1]
作者单位: Department of Psychology, University of Bath, Bath, United Kingdom. [1] Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany. [2] The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the Netherlands.;Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands. [3] Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands. [4] Department of Psychology & Neuroscience, Duke University, Durham, United States. [5] Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.;DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. [6] Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, United States. [7] GIN, IMN UMR 5293, CEA, CNRS, Université de Bordeaux, Bordeaux, France. [8] Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm, Sweden.;Department of Psychology, Stockholm University, Stockholm, Sweden.;Department of Clinical Psychology and Psychotherapy, Babeș-Bolyai University, Cluj-Napoca, Romania. [9] FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.;Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. [10] Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.;Lothian Birth Cohorts, Edinburgh Futures Institute, University of Edinburgh, Edinburgh, United Kingdom. [11] Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, United States. [12] Department of Experimental Psychology and Cognition Research, Justus-Liebig-University, Gießen, Germany. [13] Department of Psychology & Neuroscience, Duke University, Durham, United States.;Institute of Psychiatry, Psychology, & Neuroscience, King's College London, London, England. [14] Hospital Universitario Virgen del Rocio, IBIS-CSIC, CIBERSAM, Sevilla, Spain. [15] Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. [16] Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.;Center for Molecular Medicine, Stockholm, Sweden. [17] SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Tygerberg, South Africa. [18] Department of Neurology, State University of Campinas, Campinas, Brazil.;Brazilian Institute of Neuroscience and Neurotechnology, Brazil. [19] Department of Psychology, University of Oslo, Oslo, Norway.;Center for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway. [20] Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.;South Africa Medical Research Council Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, University of Cape Town, Cape Town, South Africa. [21] Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, United States. [22] Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, United States.;Department of Psychiatry, Harvard Medical School, Boston, United States. [23] School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, Australia.;Precision Medicine Research Program, Hunter Medical Research Institute, Newcastle, Australia. [24] Brazilian Institute of Neuroscience and Neurotechnology, Brazil.;Department of Medical Genetics and Genomic Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil. [25] Department of Neurology, State University of Campinas, Campinas, Brazil. [26] Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.;School of Philosophy, Psychology & Language Sciences, The University of Edinburgh, Edinburgh, United Kingdom. [27] Department of Psychiatry and Legal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.;Child Mind Institute, New York, United States. [28] Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.;German Center of Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany. [29] Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.;South Africa Medical Research Council Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. [30] Harvard T.H. Chan School of Public Health, Department of Behavioral and Social Sciences, Boston, United States.;Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands. [31] University Medicine Greifswald, Institute for Community Medicine, Greifswald, Germany. [32] Centre de recherche CHU Sainte-Justine and University of Montreal Montréal Canada. [33] Department of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, Columbus, United States. [34] Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom.;UK Dementia Research Institute Centre, University of Edinburgh, Edinburgh, United Kingdom. [35] Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas of the Rio Grande Valley, Brownsville, TX, United States. [36] Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa. [37] Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, United States.;Dept of Veterans Affairs, San Francisco, California, United States. [38] West Region, Institute of Mental Health, Singapore, Singapore. [39] Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. [40] Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm, Sweden.;Department of Clinical Psychology and Psychotherapy, Babeș-Bolyai University, Cluj-Napoca, Romania. [41] Department of Psychiatry, The University of Texas Health Science Center, Houston, United States. [42] Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.;Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia. [43] Discipline of Molecular Biology - Department of Biochemistry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. [44] Translational Psychiatry Group, Instituto de Biomedicina de Sevilla (IBiS)-CSIC, Seville, Spain.;Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. [45] Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom. [46] Division of Human Genetics, University of the Witwatersrand, Johannesburg, South Africa.;Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa. [47] School of Clinical Medicine, University of New South Wales, Sydney, Australia. [48] Center for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway. [49] Human and Systems Genetics Working Group, Department of Genetics, Stellenbosch University, Stellenbosch, South Africa. [50] Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany. [51] School of Clinical Medicine, Discipline of Psychiatry and Mental Health, University of New South Wales, Randwick, Australia. [52] Laboratory of Integrative Neurosciences (LiNC), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. [53] Department of Medical Physiology and Biophysics, Seville, Spain.;Instituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC, CIBERSAM, ISCIII, Seville, Span. [54] Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand. [55] Institute for Diagnostic Radiology and Neuroradiology, Greifswald, Germany. [56] Laboratory of Integrative Neurosciences (LiNC), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.;Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil. [57] Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.;Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. [58] Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.;The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the Netherlands. [59] Clinical Neuroimaging Laboratory, Galway Neuroscience Center, College of Medicine, Nursing & Health Sciences, University of Galway, Galway, Ireland. [60] Laboratory of Integrative Neurosciences (LiNC), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.;Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.;Graduate Program in Structural and Functional Biology, Universidade Federal de São Paulo, São Paulo, Brazil. [61] Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, United States. [62] Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, United States.;Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, United States. [63] Department of Psychology, Uppsala University, Uppsala, Sweden. [64] Departments of Psychiatry and Neuroscience, University of Montreal, Montreal, Canada. [65] Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany. [66] Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, United States. [67] NeuroRecovery Research hub, School of Psychology, UNSW Sydney, Sydney, Australia.;Centre for Pain IMPACT, Neuroscience Research Australia, Randwick, Australia. [68] Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.;Mental Health Program, Amsterdam Public Health, Amsterdam, The Netherlands.;Complex Trait Genetics program, Amsterdam Neuroscience, Amsterdam, The Netherlands. [69] Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.;Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, The Netherlands.;Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands. [70] Department of Clinical, Educational and Health Psychology London, University College London, United Kingdom. [71] Hawkes Institute, Department of Computer Science, University College London, London, United Kingdom. [72] Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.;School of Psychology, University of Queensland, Brisbane, Australia. [73] Department of Psychology and Neuroscience, City St George's, University of London, London, United Kingdom.;Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. [74]
DOI 10.64898/2025.12.23.25342890
PMID 41480039
发布时间 2026-01-22
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