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Homologous recombination deficiency in endometrial cancer: shedding light on recent clinical findings.

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第一作者： Griffin,Willman

第一单位： Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.

作者： Griffin,Willman ^[1] ; Vivek,Podder ^[2] ; Shannon Neville,Westin ^[3] ; Bradley R,Corr ^[4] ; Robert L,Coleman ^[5] ; Bhavana,Pothuri ^[6] ; Kathleen N,Moore ^[7] ; Brian M,Slomovitz ^[8]

作者单位： Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA. ^[1] Division of Gynecologic Oncology, Mount Sinai Medical Center, Miami Beach, FL, USA. ^[2] Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA. ^[3] Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado Health Cancer Center, Aurora, CO, USA. ^[4] Gynecologic Oncology, Texas Oncology, The Woodlands, TX, USA. ^[5] NYU Medical Center, Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, New York, NY, USA. ^[6] Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. ^[7] Division of Gynecologic Oncology, Mount Sinai Medical Center, Miami Beach, FL, USA. Electronic address: brian.slomovitz@msmc.com. ^[8]

关键词 Biomarkers DNA Repair Endometrial Cancer Homologous Recombination Deficiency Immunotherapy Poly(ADP-Ribose) Polymerase Inhibitors Synthetic Lethality Targeted Therapy

医学主题词人类(Humans);女(雌)性(Female);子宫内膜肿瘤(Endometrial Neoplasms);基因组不稳定性(Genomic Instability)

DOI 10.1016/j.ijgc.2025.102859

PMID 41483491

发布时间 2026-06-19

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