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Development of human single-domain antibodies against influenza based on NA-targeting IgG.

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第一作者： Ailing,Huang

第一单位： Hebei Key Laboratory of Analysis and Control of Zoonotic Pathogenic Microorganism, College of Life Sciences, Hebei Agricultural University, Hebei, 071001, China.

作者： Ailing,Huang ^[1] ; Cheng,Li ^[2] ; Hui,Wu ^[2] ; Wenli,Sun ^[2] ; Shanshan,Huo ^[1] ; Juan,Wang ^[1] ; Yanling,Wu ^[3] ; Tianlei,Ying ^[4] ; Fei,Yu ^[5]

作者单位： Hebei Key Laboratory of Analysis and Control of Zoonotic Pathogenic Microorganism, College of Life Sciences, Hebei Agricultural University, Hebei, 071001, China. ^[1] Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. ^[2] Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China; Shanghai Engineering Research Center for Synthetic Immunology, Shanghai, 200032, China. Electronic address: yanlingwu@fudan.edu.cn. ^[3] Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China; Shanghai Engineering Research Center for Synthetic Immunology, Shanghai, 200032, China. Electronic address: tlying@fudan.edu.cn. ^[4] Hebei Key Laboratory of Analysis and Control of Zoonotic Pathogenic Microorganism, College of Life Sciences, Hebei Agricultural University, Hebei, 071001, China. Electronic address: shmyf@hebau.edu.cn. ^[5]

关键词 Affinity recovery Antibody mutant library Human single-domain antibodies Influenza A virus Influenza virus neuraminidase Phage display