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CRISPR-Cas12a biosensing technology advances and applications in precision diagnostics and cancer research.

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第一作者： Ziyu,Zang

第一单位： School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, 518107, PR China.

作者： Ziyu,Zang ^[1] ; Jie,Chen ^[1] ; Yi,Dong ^[1] ; Linlin,Chen ^[1] ; Meihua,Yang ^[1] ; Meiya,Mu ^[1] ; Lirenhui,Zhou ^[1] ; Wei,Zhang ^[2] ; Guangrong,Zou ^[3] ; Chaoxing,Liu ^[4]

作者单位： School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, 518107, PR China. ^[1] Guangdong Provincial Key Laboratory of Digestive Cancer Research, Department of Gastrointestinal Surgery, Digestive Diseases Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518107, PR China. Electronic address: zhangw386@mail.sysu.edu.cn. ^[2] Department of Clinical Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 518107, PR China. Electronic address: zougr3@mail.sysu.edu.cn. ^[3] Guangdong Provincial Key Laboratory of Digestive Cancer Research, Department of Gastrointestinal Surgery, Digestive Diseases Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518107, PR China. Electronic address: liuchx69@mail.sysu.edu.cn. ^[4]

关键词 CRISPR-Cas12a Early cancer detection Nucleic acid detection Trans-cleavage Tumor microenvironment

医学主题词生物传感技术(Biosensing Techniques);人类(Humans);肿瘤(Neoplasms)

DOI 10.1016/j.talanta.2025.129298

PMID 41500123

发布时间 2026-01-15

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