首页> Zeitschrift fur Naturforschung. C, Journal of biosciences> Multiparameter optimization of broad-spectrum thymidine phosphorylase inhibition, ADMET properties, molecular docking, and DFT screening of novel pyrazole-based thiadiazole/thiazole derivatives.

Multiparameter optimization of broad-spectrum thymidine phosphorylase inhibition, ADMET properties, molecular docking, and DFT screening of novel pyrazole-based thiadiazole/thiazole derivatives.

导出 LinkOut

翻译打印收藏纠错

第一作者： Reem Nabil,Hassan

第一单位： Department of Biological Sciences, Faculty of Science, King Abdulaziz University (KAU), P.O. Box 80141, Jeddah, 21589, Saudi Arabia.

作者： Reem Nabil,Hassan ^[1] ; Hina,Sarfraz ^[2] ; Rafaqat,Hussain ^[3] ; Asma,Sardar ^[4] ; Ayaz,Ali Khan ^[5] ; Ammena Y,Binsaleh ^[6] ; Nawal,Al-Hoshani ^[7] ; Maher S,Alwethynani ^[8] ; Shaza N,Alkhatib ^[9] ; Fakhria A,Al-Joufi ^[10] ; Rania Ali El,Hadi Mohamed ^[7] ; Manal F,Elkhadragy ^[7]

作者单位： Department of Biological Sciences, Faculty of Science, King Abdulaziz University (KAU), P.O. Box 80141, Jeddah, 21589, Saudi Arabia. ^[1] Department of Chemistry, Quaid-i-Azam University Islamabad, 45320, Islamabad, Pakistan. ^[2] Department of Chemistry, Hazara University, Mansehra, Khyber Pakhtunkhwa, 21120, Pakistan. ^[3] Department of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad, 22500, Pakistan. ^[4] Department of Biotechnology, University of Malakand Chakdara, 18800, Dir Lower, KPK, Pakistan. ^[5] Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. ^[6] Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O.Box 84428, Riyadh, 11671, Saudi Arabia. ^[7] Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Alquwayiyah, Riyadh, Saudi Arabia. ^[8] Department of Biological Sciences, Collage of Sciences and Arts Khulais, University of Jeddah, Jeddah, Saudi Arabia. ^[9] Department of Pharmacology, College of Pharmacy, Jouf University, 72341, Aljouf, Saudi Arabia. ^[10]

关键词 ADMET properties multiparameter optimization novel pyrazole-based thiadiazole thiazole derivatives thymidine phosphorylase

DOI 10.1515/znc-2025-0225

PMID 41505138

发布时间 2026-01-08

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交