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Prevention of ubiquitination at K6 and K9 in mutant huntingtin exacerbates disease pathology in a knock-in mouse model.

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第一作者： Pengfei,Qi

第一单位： Department of Human Genetics, Medical Faculty, Ruhr University of Bochum, Bochum 44801, Germany.;Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen 720176, Germany.

作者： Pengfei,Qi ^[1] ; Libo,Yu-Taeger ^[1] ; Hezhou,Han ^[2] ; Junbo,Zhou ^[2] ; Elisabeth,Singer-Mikosch ^[1] ; Nicolas,Casadei ^[2] ; Olaf,Riess ^[2] ; Noam E,Ziv ^[3] ; Aaron,Ciechanover ^[4] ; Hoa Huu,Phuc Nguyen ^[5]

作者单位： Department of Human Genetics, Medical Faculty, Ruhr University of Bochum, Bochum 44801, Germany.;Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen 720176, Germany. ^[1] Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen 720176, Germany. ^[2] Network Biology Research Laboratories, Technion-Israel Institute of Technology, Haifa 3200003, Israel.;The Rappaport Faculty of Medicine and Research Institute, Haifa 3109601, Israel. ^[3] The Rappaport Faculty of Medicine and Research Institute, Haifa 3109601, Israel.;The Technion Integrated Cancer Center, Technion-Israel Institute of Technology, Haifa 3109601, Israel. ^[4] Department of Human Genetics, Medical Faculty, Ruhr University of Bochum, Bochum 44801, Germany. ^[5]

关键词 aggregation knock-in mouse model mutant huntingtin site-specific ubiquitination