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Unique gluing effect of ASXL1 K351 monoubiquitination stimulates the PR-DUB activity.

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第一作者: Tianyi,Zhang
第一单位: New Cornerstone Science Laboratory, Tsinghua-Peking Joint Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing, China.;School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Research Center for Chemical Biology of Post-Translational Modifications, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Shanghai Jiao Tong University, Shanghai, China.
作者: Tianyi,Zhang [1] ; Jiqing,Zheng [2] ; Zebing,Tong [2] ; Zhiheng,Deng [2] ; Zaozhen,He [2] ; Xiangwei,Wu [2] ; Miao,Wang [2] ; Yunxiang,Du [2] ; Ziyu,Xu [2] ; Shixian,Tao [2] ; Shizhang,Wan [3] ; Xiaolin,Tian [4] ; Haiteng,Deng [4] ; Man,Pan [5] ; Huasong,Ai [6] ; Lei,Liu [7]
作者单位: New Cornerstone Science Laboratory, Tsinghua-Peking Joint Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing, China.;School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Research Center for Chemical Biology of Post-Translational Modifications, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Shanghai Jiao Tong University, Shanghai, China. [1] New Cornerstone Science Laboratory, Tsinghua-Peking Joint Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing, China. [2] School of Pharmaceutical Sciences, Tsinghua University, Beijing, China. [3] MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China. [4] Institute of Translational Medicine, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, National Center for Translational Medicine (Shanghai), Shanghai Jiao Tong University, Shanghai, China. panman@sjtu.edu.cn.;The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. panman@sjtu.edu.cn. [5] School of Pharmaceutical Sciences, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, Research Center for Chemical Biology of Post-Translational Modifications, Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Shanghai Jiao Tong University, Shanghai, China. huasongai@sjtu.edu.cn. [6] New Cornerstone Science Laboratory, Tsinghua-Peking Joint Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing, China. lliu@mail.tsinghua.edu.cn. [7]
DOI 10.1038/s41589-025-02126-5
PMID 41513855
发布时间 2026-01-09
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Nature chemical biology

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