首页> Cancer genetics> In silico identification of deleterious NT5C2 and PRPS1 mutations driving thiopurine resistance in relapsed acute lymphoblastic leukemia.

In silico identification of deleterious NT5C2 and PRPS1 mutations driving thiopurine resistance in relapsed acute lymphoblastic leukemia.

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第一作者： Ramita,Sharma

第一单位： Research and Development, Indo-American Cancer Research Foundation, Basavatarakam Indo-American Cancer Hospital and Research Institute, Banjara Hills, Hyderabad, Telangana 500034, India; School of Bioengineering and Biosciences, Lovely Professional University, Punjab, India.

作者： Ramita,Sharma ^[1] ; Jeeshitha,Kudithipudi ^[2] ; Himanshu,Singh ^[3] ; Dhamodharan,Prabhu ^[4] ; Sugunakar,Vuree ^[5]

作者单位： Research and Development, Indo-American Cancer Research Foundation, Basavatarakam Indo-American Cancer Hospital and Research Institute, Banjara Hills, Hyderabad, Telangana 500034, India; School of Bioengineering and Biosciences, Lovely Professional University, Punjab, India. ^[1] Department of Biotechnology, KL University (Deemed to be), Greenfields, Vaddeswaram, Guntur, Andhra Pradesh 522302, India. ^[2] School of Bioengineering and Biosciences, Lovely Professional University, Punjab, India. ^[3] Centre for Bioinformatics, Karpagam Academy of Higher Education, Coimbatore, 641021, India; Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, 641021, India. ^[4] Research and Development, Indo-American Cancer Research Foundation, Basavatarakam Indo-American Cancer Hospital and Research Institute, Banjara Hills, Hyderabad, Telangana 500034, India. Electronic address: sugunakarvure@gmail.com. ^[5]

关键词 In silico analysis MD simulation Molecular docking Relapsed acute lymphoblastic leukemia Thiopurine resistance nsSNPs

医学主题词人类(Humans);前体细胞淋巴母细胞白血病淋巴瘤(Precursor Cell Lymphoblastic Leukemia-Lymphoma);抗药性, 肿瘤(Drug Resistance, Neoplasm);5'-核苷酸酶(5'-Nucleotidase);突变(Mutation);计算机模拟(Computer Simulation)

DOI 10.1016/j.cancergen.2026.01.001

PMID 41518974

发布时间 2026-03-15

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