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Mathematical analysis of metronomic chemotherapy response in metastatic gastrointestinal cancer: identifying critical parameters from clinical data.

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第一作者： Maria Laura,Manca

第一单位： Department of Clinical & Experimental Medicine, University of Pisa, and Hospital-University of Pisa, Pisa, Italy. laura.manca@unipi.it.

作者： Maria Laura,Manca ^[1] ; Alessandro,Michelangeli ^[2] ; Guido,Bocci ^[3] ; Paola,Orlandi ^[4] ; Giacomo,Allegrini ^[5] ; Robert A,Kirken ^[6] ; Giulio,Francia ^[6] ; Vladimir,Georgiev ^[7]

作者单位： Department of Clinical & Experimental Medicine, University of Pisa, and Hospital-University of Pisa, Pisa, Italy. laura.manca@unipi.it. ^[1] Mathematics and Science Department, AUBG Blagoevgrad, Blagoevgrad, Bulgaria. alessandro.michelangeli@gmail.com.;Hausdorff Center for Mathematics, HCM Bonn, Bonn, Germany. alessandro.michelangeli@gmail.com.;Trieste Institute for Theoretical Quantum Technologies, TQT Trieste, Trieste, Italy. alessandro.michelangeli@gmail.com. ^[2] Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. ^[3] Department of Clinical & Experimental Medicine, University of Pisa, and Hospital-University of Pisa, Pisa, Italy. ^[4] Division of Medical Oncology, Leghorn Hospital, Livorno, Italy. ^[5] University of Texas at El Paso (UTEP), Paso, USA. ^[6] Department of Mathematics, University of Pisa, Paso, Italy.;Faculty of Science and Engineering, Waseda University, Tokyo, Japan.;Institute of Mathematics and Informatics, Bulgarian Academy of Sciences, Sofia, Bulgaria. ^[7]

关键词 Cancer therapy and parameter optimisation Mathematical modelling in oncology Metastatic gastrointestinal cancers Metronomic chemotherapy Progression-free survival Treatment function Tumour angiogenesis