首页> Toxicology and applied pharmacology> GSDMD inhibitor GI-Y1 alleviates doxorubicin-induced cardiotoxicity via the inhibition of mitochondrial dysfunction.

GSDMD inhibitor GI-Y1 alleviates doxorubicin-induced cardiotoxicity via the inhibition of mitochondrial dysfunction.

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第一作者： Yucong,Zhang

第一单位： Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Geriatric Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China; The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.

作者： Yucong,Zhang ^[1] ; Ruihan,Zheng ^[2] ; Minne,Xie ^[3] ; Yunxuan,Chen ^[4] ; Binbin,Xia ^[4] ; Zexin,Yang ^[5] ; Zhuoning,Li ^[4] ; Yuzheng,Li ^[4] ; Li,Luo ^[4] ; Weijian,Huang ^[4] ; Shanshan,Dai ^[6] ; Bozhi,Ye ^[7] ; Wenli,Zhang ^[8]

作者单位： Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Geriatric Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China; The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. ^[1] Department of Geriatric Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China; The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. ^[2] Department of Cardiology, Yuhuan County People's Hospital of Zhejiang Province, Taizhou, China. ^[3] The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. ^[4] The Key Laboratory of Emergency and Disaster Medicine of Wenzhou, Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People's Republic of China. ^[5] The Key Laboratory of Emergency and Disaster Medicine of Wenzhou, Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People's Republic of China. Electronic address: shanshandai137@163.com. ^[6] Department of Geriatric Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China; The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. Electronic address: fredye2012@163.com. ^[7] Department of Geriatric Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China. Electronic address: 13917615339@163.com. ^[8]

关键词 Doxorubicin-induced cardiotoxicity GI-Y1 GSDMD Mitochondrial damage Pyroptosis