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Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress response.

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第一作者： Viktor Antonsson,Garellick

第一单位： Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, 405 30, Sweden; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, 405 30, Sweden.

作者： Viktor Antonsson,Garellick ^[1] ; Nadia,Gul ^[2] ; Parvin,Horrieh ^[3] ; Dyar,Mustafa ^[2] ; Angana A H,Patel ^[4] ; Martin,Dankis ^[4] ; Samantha W,Alvarez ^[4] ; Johanna,Berndtson ^[3] ; Saeed,Mahdavi ^[3] ; Maria,Schwarz ^[5] ; Andreas,Persson ^[3] ; Fikret,Zahirovic ^[3] ; Clotilde,Wiel ^[4] ; Volkan I,Sayin ^[6] ; Per,Lindahl ^[7]

作者单位： Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, 405 30, Sweden; Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, 405 30, Sweden. ^[1] Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, 405 30, Sweden; Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, 405 30, Sweden. ^[2] Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, 405 30, Sweden. ^[3] Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, 405 30, Sweden; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, 405 30, Sweden. ^[4] Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, 405 30, Sweden; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, 405 30, Sweden; Department of Nutritional Physiology, Institute of Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Str. 24, Jena, 07743, Germany. ^[5] Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, 405 30, Sweden; Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, 405 30, Sweden; The Wallenberg Centre for Molecular and Translational Medicine, at Sahlgrenska Academy, University of Gothenburg, Gothenburg, 405 30, Sweden. ^[6] Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, 405 30, Sweden; Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, 405 30, Sweden. Electronic address: per.lindahl@wlab.gu.se. ^[7]

关键词 Amino acids Ferroptosis Glutathione Integrated stress response Lung cancer Mitochondrial respiration