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Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.

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第一作者： Wonji,Kim

第一单位： Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.

作者： Wonji,Kim ^[1] ; Xiaowei,Hu ^[2] ; Kangjin,Kim ^[3] ; Sung,Chun ^[4] ; Peter,Orchard ^[5] ; Dandi,Qiao ^[1] ; Ingo,Ruczinski ^[6] ; Aabida,Saferali ^[1] ; Francois,Aguet ^[7] ; Lucinda,Antonacci-Fulton ^[8] ; Pallavi P,Balte ^[9] ; Traci M,Bartz ^[10] ; Wardatul Jannat,Anamika ^[1] ; Xiaobo,Zhou ^[1] ; JunYi,Duan ^[1] ; Jennifer A,Brody ^[11] ; Brian E,Cade ^[12] ; Martha L,Daviglus ^[13] ; Harshavadran,Doddapaneni ^[14] ; Shannon,Dugan-Perez ^[14] ; Susan K,Dutcher ^[8] ; Christian D,Frazar ^[15] ; Stacey B,Gabriel ^[16] ; Sina A,Gharib ^[17] ; Namrata,Gupta ^[16] ; Brian D,Hobbs ^[1] ; Silva,Kasela ^[18] ; Laura R,Loehr ^[19] ; Ginger A,Metcalf ^[14] ; Donna M,Muzny ^[14] ; Elizabeth C,Oelsner ^[20] ; Laura J,Rasmussen-Torvik ^[21] ; Colleen M,Sitlani ^[11] ; Joshua,Smith ^[22] ; Tamar,Sofer ^[23] ; Hanfei,Xu ^[24] ; Bing,Yu ^[25] ; David,Zhang ^[26] ; John,Ziniti ^[1] ; R Graham,Barr ^[20] ; April P,Carson ^[27] ; Myriam,Fornage ^[28] ; Lifang,Hou ^[21] ; Ravi,Kalhan ^[29] ; Robert,Kaplan ^[30] ; Tuuli,Lappalainen ^[31] ; Stephanie J,London ^[32] ; Alanna C,Morrison ^[33] ; George T,O'Connor ^[34] ; Bruce M,Psaty ^[35] ; Laura M,Raffield ^[36] ; Susan,Redline ^[37] ; Stephen S,Rich ^[2] ; Jerome I,Rotter ^[9] ; Edwin K,Silverman ^[1] ; Ani,Manichaikul ^[38] ; Michael H,Cho ^[39]

作者单位： Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA. ^[1] Department of Genome Sciences, University of Virginia School of Medicine, West Complex Room 6115, Charlottesville, VA, 22908, USA. ^[2] Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.;Department of Applied Statistics, Gachon University, Seongnam, Republic of Korea. ^[3] Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.;Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA. ^[4] Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA. ^[5] Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ^[6] Illumina Artificial Intelligence Laboratory, Illumina, Inc., San Diego, CA, USA. ^[7] Department of Genetics, Washington University in St Louis, St Louis, MO, USA. ^[8] The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. ^[9] Cardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA. ^[10] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. ^[11] Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA. ^[12] Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA. ^[13] Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA. ^[14] University of Washington, Seattle, WA, USA. ^[15] Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[16] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.;Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA. ^[17] New York Genome Center, New York, NY, USA. ^[18] Division of General Medicine and Clinical Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[19] Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY, USA. ^[20] Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. ^[21] Northwest Genomic Center, University of Washington, Seattle, WA, USA. ^[22] Division of Sleep and Circadian Disorder, Brigham and Women's Hospital, Boston, MA, USA. ^[23] Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA. ^[24] Department of Epidemiology, School of Public Health, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA. ^[25] Department of Medicine and Institute for Genomic Medicine, Irving Medical Center, Columbia University, New York, NY, USA. ^[26] Department of Medicine, University of Mississippi, Jackson, MS, USA. ^[27] Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health at Houston, Houston, TX, USA. ^[28] Department of Preventive Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. ^[29] Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. ^[30] New York Genome Center, New York, NY, USA.;Department of Systems Biology, Columbia University, New York, NY, USA. ^[31] Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Chapel Hill, NC, USA. ^[32] Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA. ^[33] Pulmonary Center, Boston University School of Medicine, Boston, MA, USA. ^[34] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.;Departments of Epidemiology and Health Systems and Population Health, University of Washington, Seattle, WA, USA. ^[35] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[36] Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. ^[37] Department of Genome Sciences, University of Virginia School of Medicine, West Complex Room 6115, Charlottesville, VA, 22908, USA. amanicha@virginia.edu. ^[38] Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA. remhc@channing.harvard.edu. ^[39]

关键词 COPD CRISPR knockdown Colocalization with molecular QTLs Fine-mapping Lung function Lung tissue single-cell RNA-seq validation Multi-ancestry GWAS