换一批COLEC12high tumor-associated macrophages orchestrate lenvatinib resistance and cancer stemness in hepatocellular carcinoma via paracrine NRG1-HER2/HER3 signaling.
第一作者：
Jianxing,Zhang
第一单位：
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.;Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
作者：
医学主题词
癌, 肝细胞(Carcinoma, Hepatocellular);人类(Humans);肝肿瘤(Liver Neoplasms);喹啉类(Quinolines);抗药性, 肿瘤(Drug Resistance, Neoplasm);苯脲化合物(Phenylurea Compounds);动物(Animals);小鼠(Mice);神经调节蛋白1(Neuregulin-1);信号传导(Signal Transduction);肿瘤干细胞(Neoplastic Stem Cells);细胞系, 肿瘤(Cell Line, Tumor);旁分泌细胞细胞间通讯(Paracrine Communication);STAT1转录因子(STAT1 Transcription Factor)
DOI
10.3350/cmh.2025.1059
PMID
41555545
发布时间
2026-05-02
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