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Regulatory T-cell Sensing of Extracellular ATP via P2RX7 Promotes Their Accumulation and Suppression and Drives Lung Tumor Growth.

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第一作者： Igor,Santiago-Carvalho

第一单位： Department of Immunology, Mayo Clinic, Phoenix, Arizona.

作者： Igor,Santiago-Carvalho ^[1] ; Ronaldo,Francisco ^[2] ; Bruna Gois,Macedo ^[1] ; Caio Loureiro,Salgado ^[1] ; Carly R,Stoll ^[1] ; Samantha,Shao ^[1] ; Angad,Beniwal ^[1] ; Tina,Kwok ^[1] ; Alma,Banuelos ^[1] ; Marcos Pinheiro,Cione ^[3] ; Emily,White ^[1] ; Tyler M,Johnston ^[1] ; Chloe Liliana,Leff ^[1] ; Ildefonso,Silva Junior ^[1] ; Fabio,Carvalho de Souza ^[1] ; Win,Thant ^[1] ; Prita,Pandya ^[4] ; Maria Regina,D'Império Lima ^[5] ; Sebastian,Fernandez-Bussy ^[6] ; David,Abia-Trujillo ^[6] ; Linh H,Vu ^[6] ; Nhan L,Tran ^[7] ; Bryan C,Husta ^[6] ; John A,Copland ^[4] ; Fotini,Gounari ^[1] ; Verline,Justilien ^[4] ; Jessica Naomi,Lancaster ^[1] ; Henrique,Borges da Silva ^[8]

作者单位： Department of Immunology, Mayo Clinic, Phoenix, Arizona. ^[1] Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. ^[2] Department of Immunology, Mayo Clinic, Phoenix, Arizona.;Department of Immunology, University of Sao Paulo, Sao Paulo, Brazil. ^[3] Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida. ^[4] Department of Immunology, University of Sao Paulo, Sao Paulo, Brazil. ^[5] Division of Pulmonary, Allergy and Sleep Medicine, Mayo Clinic, Jacksonville, Florida. ^[6] Department of Cancer Biology, Mayo Clinic, Phoenix, Arizona. ^[7] Department of Immunology, Mayo Clinic, Phoenix, Arizona.;Department of Cancer Biology, Mayo Clinic, Phoenix, Arizona. ^[8]

医学主题词动物(Animals);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);受体, 嘌呤能P2X7(Receptors, Purinergic P2X7);小鼠(Mice);肺肿瘤(Lung Neoplasms);腺苷三磷酸(Adenosine Triphosphate);小鼠, 基因敲除(Mice, Knockout);小鼠, 近交C57BL(Mice, Inbred C57BL);人类(Humans);细胞系, 肿瘤(Cell Line, Tumor);癌, Lewis肺(Carcinoma, Lewis Lung);疾病模型, 动物(Disease Models, Animal)

DOI 10.1158/2326-6066.CIR-25-0567

PMID 41564348

发布时间 2026-04-02

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Regulatory T-cell Sensing of Extracellular ATP via P2RX7 Promotes Their Accumulation and Suppression and Drives Lung Tumor Growth.

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Regulatory T-cell Sensing of Extracellular ATP via P2RX7 Promotes Their Accumulation and Suppression and Drives Lung Tumor Growth.

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