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Regulatory T-cell sensing of extracellular ATP via P2RX7 promotes their accumulation and suppression and drives lung tumor growth.

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第一作者： Igor,Santiago-Carvalho

第一单位： Mayo Clinic Phoenix, Arizona United States.

作者： Igor,Santiago-Carvalho ^[1] ; Ronaldo,Francisco ^[2] ; Bruna,de Gois Macedo ^[3] ; Caio Loureiro,Salgado ^[1] ; Carly R,Stoll ^[1] ; Samantha,Shao ^[1] ; Angad,Beniwal ^[1] ; Tina,Kwok ^[1] ; Alma,Banuelos ^[3] ; Marcos Pinheiro,Cione ^[1] ; Emily,White ^[1] ; Tyler M,Johnston ^[1] ; Chloe Liliana,Leff ^[1] ; Ildefonso,Silva-Junior ^[1] ; Fabio,Carvalho de Souza ^[1] ; Win,Thant ^[4] ; Prita,Pandya ^[5] ; Maria Regina,D'Imperio Lima ^[6] ; Sebastian,Fernandez-Bussy ^[7] ; David,Abia-Trujillo ^[5] ; Linh H,Vu ^[8] ; Nhan L,Tran ^[9] ; Bryan C,Husta ^[5] ; John A,Copland ^[7] ; Fotini,Gounari ^[1] ; Verline,Justilien ^[5] ; Jessica Naomi,Lancaster ^[1] ; Henrique,Borges da Silva ^[1]

作者单位： Mayo Clinic Phoenix, Arizona United States. ^[1] Brigham and Women's Hospital Boston, Massachusetts United States. ^[2] Mayo Clinic Scottsdale, Arizona United States. ^[3] Massachusetts General Hospital Boston United States. ^[4] Mayo Clinic Jacksonville, Florida United States. ^[5] Universidade de São Paulo Sao Paulo, Sao Paulo Brazil. ^[6] Mayo Clinic Jacksonville, FL United States. ^[7] Mayo Clinic United States. ^[8] Mayo Clinic Scottsdale, AZ United States. ^[9]

DOI 10.1158/2326-6066.CIR-25-0567

PMID 41564348

发布时间 2026-01-21

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Regulatory T-cell sensing of extracellular ATP via P2RX7 promotes their accumulation and suppression and drives lung tumor growth.

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Regulatory T-cell sensing of extracellular ATP via P2RX7 promotes their accumulation and suppression and drives lung tumor growth.

Cancer immunology research

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Cancer immunology research

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