首页> Scientific reports> Structural and computational supported development of 2,5-disubstituted-1,3,4-oxadiazole analogues as active LOX, urease, and α-glucosidase inhibitors.

Structural and computational supported development of 2,5-disubstituted-1,3,4-oxadiazole analogues as active LOX, urease, and α-glucosidase inhibitors.

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第一作者： Jamila,Javid

第一单位： Department of Chemistry, Government College University, Lahore, 54000, Pakistan.

作者： Jamila,Javid ^[1] ; Aziz-Ur-Rehman ^[1] ; Javed,Iqbal ^[2] ; Ijaz,Ahmed ^[3] ; Nadia,Bhatti ^[4] ; Aleksey,Kuznetsov ^[5] ; Fatiqa,Zafar ^[4] ; Muhammad Adnan,Ayub ^[4] ; Osama A,Mohammed ^[6] ; Samiah H,Al-Mijalli ^[7] ; Munawar,Iqbal ^[8] ; Syed A Ali,Shah ^[9]

作者单位： Department of Chemistry, Government College University, Lahore, 54000, Pakistan. ^[1] Department of Chemistry, University of Sahiwal, Sahiwal, 57000, Pakistan. javediqbal.chemist@gmail.com. ^[2] School of Chemistry, University of the Punjab, Lahore, 54590, Pakistan. ^[3] Department of Chemistry, University of Sahiwal, Sahiwal, 57000, Pakistan. ^[4] Departamento de Química, Campus Santiago Vitacura, Universidad Técnica Federico Santa María, Vitacura, 7660251, Santiago, Chile. ^[5] Department of Pharmacology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia. ^[6] Department of Biology, College of Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. ^[7] Renewable Energy and Environmental Technology Center, University of Tabuk, Tabuk, 47913, Saudi Arabia.;School of Chemistry, University of the Punjab, Lahore , 54590, Pakistan. ^[8] Faculty of Pharmacy, Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam, Puncak Alam, 42300, Selangor, Malaysia.;Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam, Puncak Alam, 42300, Selangor, Malaysia. ^[9]

关键词 1,3,4-Oxadiazole Acetyl cholinesterase DFT study Inhibition Lipoxygenase Urease

DOI 10.1038/s41598-026-35499-1

PMID 41565832

发布时间 2026-02-14

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