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ALDH2 and NFκB Activation Restores VEGFR2 Expression and Angiogenesis Impaired by 4-HNE in Coronary Endothelial Cells.

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第一作者： Bipradas,Roy

第一单位： Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, USA.;Department of Physiology, Wayne State University, Detroit, Michigan, USA.

作者： Bipradas,Roy ^[1] ; Emmanuel Oppong,Yeboah ^[1] ; Rajarajan Amirthalingam,Thandavarayan ^[2] ; Michael C,Petriello ^[3] ; Shailendra,Giri ^[4] ; Suresh Selvaraj,Palaniyandi ^[1]

作者单位： Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, USA.;Department of Physiology, Wayne State University, Detroit, Michigan, USA. ^[1] Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, Texas, USA. ^[2] Institute of Environmental Health Sciences, Wayne State University, Detroit, Michigan, USA.;Department of Pharmacology, Wayne State University, Detroit, Michigan, USA. ^[3] Department of Neurology, Henry Ford Health, Detroit, Michigan, USA. ^[4]

关键词 4‐hydroxy‐2‐Nonenal (4HNE)aldehyde dehydrogenase 2 (ALDH2)angiogenesis coronary endothelial cells (CECs)heart failure with preserved ejection fraction (HFpEF)nuclear factor kappa B (NFκB)vascular endothelial growth factor receptor 2 (VEGFR2)