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TGFBI deficiency facilitates tumor associated macrophages M2 polarization and angiogenesis to promote pancreatic neuroendocrine neoplasms progression.

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第一作者： Pengfei,Liu

第一单位： Department of Gastroenterology, The Jiangyin Clinical College of Xuzhou Medical University, Jiangyin People's Hospital, Jiangyin, 214400, China.

作者： Pengfei,Liu ^[1] ; Lin,Xu ^[2] ; Qin,Long ^[2] ; Fengjuan,Chen ^[3] ; Xinyun,Qiang ^[2] ; Xu,Han ^[2] ; Jinxing,Bao ^[4] ; Wei,Sun ^[5] ; Ruitong,Xu ^[6] ; Mujie,Ye ^[7]

作者单位： Department of Gastroenterology, The Jiangyin Clinical College of Xuzhou Medical University, Jiangyin People's Hospital, Jiangyin, 214400, China. ^[1] Department of Neuroendocrine Tumor, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China. ^[2] Department of Gastroenterology, Xishan People's Hospital of Wuxi City, Wuxi, 214001, China. ^[3] Department of Geriatric, The First People's Hospital of Lianyungang, Xuzhou Medical University Affiliated Hospital of Lianyungang (Lianyungang Clinical College of Nanjing Medical University), Lianyungang, 222001, China. baojx2012@126.com. ^[4] Department of Gastroenterology, Huai'an NO3. People's Hospital, Huai'an NO2 Clinical College of Xuzhou Medical University, Huai'an, 223001, China. 405771860@qq.com. ^[5] Department of Geriatric Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China. fangxrt@163.com. ^[6] Department of Gastroenterology, The Jiangyin Clinical College of Xuzhou Medical University, Jiangyin People's Hospital, Jiangyin, 214400, China. mujiey0629@163.com.;Department of Neuroendocrine Tumor, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, China. mujiey0629@163.com. ^[7]

关键词 Angiogenesis M2-like polarization Pancreatic neuroendocrine neoplasms TGFBI Tumor-associated macrophage

DOI 10.1186/s12935-026-04194-6

PMID 41582145

发布时间 2026-06-25

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