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Industry Practices in Oligonucleotide Tissue Biodistribution Assessment: An IQ consortium Cross-Industry Survey of Current Approaches and Emerging Trends.

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第一作者： Michael,McCoy

第一单位： DMPK & Modeling, Takeda Pharmaceuticals, 35 Landsdowne St, Cambridge, Massachusetts, 02139, USA. Michael.McCoy1@takeda.com.

作者： Michael,McCoy ^[1] ; Huaping,Tang ^[2] ; Lydia,Michaut ^[3] ; Irina,Laczkovich ^[4] ; Girish,Chopda ^[5] ; Linzhi,Chen ^[6] ; Isha,Taneja ^[7] ; C Andrew,Boswell ^[8] ; Guangnong,Zhang ^[9]

作者单位： DMPK & Modeling, Takeda Pharmaceuticals, 35 Landsdowne St, Cambridge, Massachusetts, 02139, USA. Michael.McCoy1@takeda.com. ^[1] Biomarker and Bioanalytical Platforms, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, Pennsylvania, USA. ^[2] PK Sciences, Novartis Biomedical Research, Basel, Switzerland. ^[3] Translational Biomarkers and Bioanalytics, Takeda Pharmaceuticals, Cambridge, Massachusetts, USA. ^[4] DMPK, Novo Nordisk, Lexington, Massachusetts, USA. ^[5] Global Nonclinical Safety & DMPK, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, USA. ^[6] Translational Pharmacokinetics, Pharmacodynamics and Investigational Toxicology, Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA. ^[7] Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc, 1 DNA Way, South San Francisco, California, USA. ^[8] Nucleic Acid Research, Novo Nordisk US R&D, Lexington, Massachusetts, USA. ^[9]

关键词 IQ consortium PK/PD bioanalysis oligonucleotide therapeutics tissue biodistribution

医学主题词制药工业(Drug Industry);人类(Humans);寡核苷酸类(Oligonucleotides);组织分布(Tissue Distribution);动物(Animals);寡核苷酸类, 反义(Oligonucleotides, Antisense)

DOI 10.1208/s12248-026-01209-y

PMID 41612090

发布时间 2026-03-26

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准确一般字义偏差语意偏离译文作用小提交