首页> Molecular therapy : the journal of the American Society of Gene Therapy> Enhancing adoptive T cell therapy by disrupting the SKI-SMAD2/3 axis to counteract TGF-β-mediated immunosuppression.

Enhancing adoptive T cell therapy by disrupting the SKI-SMAD2/3 axis to counteract TGF-β-mediated immunosuppression.

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第一作者： Xiaohan,Jin

第一单位： Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China; School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

作者： Xiaohan,Jin ^[1] ; Jingxuan,Yu ^[2] ; Xinyu,Wu ^[3] ; Qingyong,Hu ^[3] ; Xixi,Chen ^[3] ; Wenbo,Ma ^[4] ; Yude,Guan ^[5] ; Dongmei,Guo ^[3] ; Yulan,Yang ^[3] ; Lingyu,Wang ^[3] ; Guofei,Jin ^[3] ; Zhenglan,Han ^[3] ; Shumin,Zhang ^[3] ; Nianchao,Zhang ^[6]

作者单位： Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China; School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, China. ^[1] Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China; Department of Immunology & State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China. ^[2] Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. ^[3] School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China. ^[4] Key Laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China. ^[5] Institute of Basic Medicine, North Sichuan Medical College, Nanchong, Sichuan, China. Electronic address: nianchaoz@nsmc.edu.cn. ^[6]

关键词 SKI TGF-β signaling adoptive T cell therapy anti-tumor efficiency immunosuppression