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An oncogenic KRAS-driven secretome involving TNFα promotes niche preparation prior to pancreatic cancer onset.

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第一作者: Chantal,Allgöwer
第一单位: Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
作者单位: Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Albert-Einstein-Allee 23, 89081, Ulm, Germany. [1] Single Cell Sequencing Unit, Ulm University, Ulm, Germany. [2] Institute for Computational Genomics, Center for Computational Life Sciences, RWTH Aachen Medical Faculty, Aachen, Germany. [3] Helmholtz Pioneer Campus, Helmholtz Munich, Munich, Germany. [4] Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy. [5] Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.;Vita-Salute San Raffaele University, Milan, Italy. [6] Department for Microphysiological Systems, Institute of Biomedical Engineering, Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.;NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.;3R Center Tübingen for In Vitro Models and Alternatives to Animal Testing, Tübingen, Germany. [7] Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road M20 4BX, Manchester, UK. [8] Department for Microphysiological Systems, Institute of Biomedical Engineering, Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.;NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany. [9] Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany. [10] Institute of Pathology, Ulm University Hospital, Ulm, Germany. [11] Core Facility Organoids, Ulm University, Ulm, Germany. [12] Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Albert-Einstein-Allee 23, 89081, Ulm, Germany.;Department of Urology, Ulm University Hospital, Ulm, Germany. [13] Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden. [14] Institute of Neuroanatomy & Developmental Biology, Eberhard Karls University Tübingen, Tübingen, Germany. [15] Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.;Vita-Salute San Raffaele University, Milan, Italy.;Department of Pancreatic Surgery, Pancreas Translational and Clinical Research Center, IRCCS Ospedale San Raffaele, Milan, Italy. [16] Vita-Salute San Raffaele University, Milan, Italy.;Department of Pancreatic Surgery, Pancreas Translational and Clinical Research Center, IRCCS Ospedale San Raffaele, Milan, Italy. [17] Helmholtz Pioneer Campus, Helmholtz Munich, Munich, Germany.;Center for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany. [18] Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Albert-Einstein-Allee 23, 89081, Ulm, Germany. markus.breunig@uni-ulm.de. [19] Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Albert-Einstein-Allee 23, 89081, Ulm, Germany. alexander.kleger@uni-ulm.de.;Core Facility Organoids, Ulm University, Ulm, Germany. alexander.kleger@uni-ulm.de.;Division of Interdisciplinary Pancreatology, Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany. alexander.kleger@uni-ulm.de. [20]
DOI 10.1186/s12943-025-02541-1
PMID 41634803
发布时间 2026-06-25
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