换一批
第一作者：
Xin,Li
第一单位：
Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
作者：
Xin,Li [1]
;
Cynthia,Lebeaupin [2]
;
Aikaterini,Kadianaki [1]
;
Clementine,Druelle-Cedano [3]
;
Niklas,Vesper [4]
;
Charlotte,Rennert [5]
;
Júlia,Huguet-Pradell [6]
;
Borja,Gomez Ramos [7]
;
Chaofan,Fan [1]
;
Robert Stefan,Piecyk [8]
;
Laimdota,Zizmare [9]
;
Pierluigi,Ramadori [10]
;
Luqing,Li [11]
;
Lukas,Frick [12]
;
Menjie,Qiu [13]
;
Cangang,Zhang [14]
;
Luiza,Martins Nascentes Melo [15]
;
Vikas Prakash,Ranvir [1]
;
Peng,Shen [1]
;
Johannes,Hanselmann [13]
;
Jan,Kosla [11]
;
Mirian,Fernández-Vaquero [1]
;
Mihael,Vucur [16]
;
Praveen,Baskaran [17]
;
Xuanwen,Bao [18]
;
Olivia I,Coleman [19]
;
Yingyue,Tang [20]
;
Miray,Cetin [21]
;
Zhouji,Chen [3]
;
Insook,Jang [3]
;
Stefania,Del Prete [22]
;
Mohammad,Rahbari [11]
;
Peng,Zhang [23]
;
Timothy V,Pham [24]
;
Yushan,Hou [25]
;
Aihua,Sun [25]
;
Li,Gu [26]
;
Laura C,Kim [27]
;
Ulrike,Rothermel [11]
;
Danijela,Heide [11]
;
Adnan,Ali [11]
;
Suchira,Gallage [10]
;
Nana,Talvard-Balland [28]
;
Marta,Piqué-Gili [29]
;
Albert,Gris-Oliver [29]
;
Alessio,Bevilacqua [30]
;
Lisa,Schlicker [31]
;
Alec,Duffey [3]
;
Kristian,Unger [32]
;
Marta,Szydlowska [11]
;
Jenny,Hetzer [11]
;
Duncan T,Odom [22]
;
Tim,Machauer [11]
;
Daniele,Bucci [33]
;
Pooja,Sant [34]
;
Jun-Hoe,Lee [17]
;
Jonas,Rösler [35]
;
Sven W,Meckelmann [35]
;
Johannes,Schreck [20]
;
Sue,Murray [36]
;
M Celeste,Simon [27]
;
Sven,Nahnsen [37]
;
Almut,Schulze [31]
;
Ping-Chih,Ho [38]
;
Manfred,Jugold [39]
;
Kai,Breuhahn [20]
;
Jan-Philipp,Mallm [34]
;
Peter,Schirmacher [20]
;
Susanne,Roth [40]
;
Nuh,Rahbari [41]
;
Darjus F,Tschaharganeh [20]
;
Stephanie,Roessler [20]
;
Benjamin,Goeppert [42]
;
Bertram,Bengsch [43]
;
Geoffroy,Andrieux [44]
;
Melanie,Boerries [45]
;
Nisar P,Malek [46]
;
Marco,Prinz [47]
;
Achim,Weber [48]
;
Robert,Zeiser [28]
;
Pablo,Tamayo [49]
;
Peter,Bronsert [50]
;
Konrad,Kurowski [50]
;
Robert,Thimme [5]
;
Detian,Yuan [23]
;
Rafael,Carretero [51]
;
Tom,Luedde [16]
;
Roser,Pinyol [29]
;
Felix J,Hartmann [52]
;
Michael,Karin [53]
;
Alpaslan,Tasdogan [15]
;
Christoph,Trautwein [54]
;
Moritz,Mall [7]
;
Maike,Hofmann [5]
;
Josep M,Llovet [55]
;
Dirk,Haller [56]
;
Randal J,Kaufman [57]
;
Mathias,Heikenwälder [58]
作者单位：
Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
[1]
Center for Metabolic and Liver Disease, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. cynthia.lebeaupin@gmail.com.
[2]
Center for Metabolic and Liver Disease, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
[3]
Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Faculty of Biology, University of Freiburg, Freiburg, Germany.
[4]
Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[5]
Liver Cancer Translational Research Group, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.;Mount Sinai Liver Cancer Program, Divisions of Liver Diseases, Department of Hematology/Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[6]
Division of Cell Fate Engineering and Disease Modeling, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.;HITBR Hector Institute for Translational Brain Research, Heidelberg, Germany.;Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
[7]
Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.;Bavarian Cancer Research Center (BZKF), Munich, Germany.
[8]
Werner Siemens Imaging Center (WSIC), Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.;Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.
[9]
Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.;M3-Research Center for Malignome, Metabolome and Microbiome, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, Faculty of Medicine, University of Tübingen, Tübingen, Germany.
[10]
Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[11]
Institute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
[12]
M3-Research Center for Malignome, Metabolome and Microbiome, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, Faculty of Medicine, University of Tübingen, Tübingen, Germany.
[13]
Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
[14]
Department of Dermatology, University Hospital Essen, Essen, Germany.;German Cancer Consortium (DKTK) Partner Site, Essen, Germany.
[15]
Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty at Heinrich-Heine-University, Düsseldorf, Germany.
[16]
Quantitative Biology Center (QBiC), Eberhard Karls University Tübingen, Tübingen, Germany.
[17]
Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
[18]
Chair of Nutrition and Immunology, Technische Universität München, Freising, Germany.
[19]
Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
[20]
Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.;Systems Immunology and Single-Cell Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[21]
Division of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[22]
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
[23]
Center for Novel Therapeutics and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
[24]
State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Institute of Lifeomics, Beijing, China.
[25]
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA.;Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.;Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China.
[26]
Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA.
[27]
Department of Hematology and Oncology, Freiburg University Medical Centre, Freiburg, Germany.
[28]
Liver Cancer Translational Research Group, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
[29]
Department of Oncology, University of Lausanne, Epalinges, Switzerland.
[30]
Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[31]
Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.;Bavarian Cancer Research Center (BZKF), Munich, Germany.;German Cancer Consortium (DKTK), Partner Site Munich, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany.;Research Unit Translational Metabolic Oncology (TMO), Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Munich, Neuherberg, Germany.;German Center for Diabetes Research (DZD), Neuherberg, Germany.
[32]
Werner Siemens Imaging Center (WSIC), Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.
[33]
Single-Cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[34]
Applied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany.
[35]
Ionis Pharmaceuticals, Carlsbad, CA, USA.
[36]
Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.;Quantitative Biology Center (QBiC), Eberhard Karls University Tübingen, Tübingen, Germany.;Biomedical Data Science, Department of Computer Science, University of Tübingen, Tübingen, Germany.
[37]
Department of Oncology, University of Lausanne, Epalinges, Switzerland.;Ludwig institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
[38]
Core Facility Small Animal Imaging, German Cancer Research Center Heidelberg, Heidelberg, Germany.
[39]
M3-Research Center for Malignome, Metabolome and Microbiome, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, Faculty of Medicine, University of Tübingen, Tübingen, Germany.;Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.;Department of General, Visceral and Transplantation Surgery, Tübingen University Hospital, Tübingen, Germany.
[40]
Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
[41]
Institute of Pathology, RKH Hospital, Ludwigsburg, Germany.;Institute of Tissue Medicine and Pathology, University of Berne, Berne, Switzerland.
[42]
Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
[43]
Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[44]
Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.;German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Freiburg, Germany.
[45]
M3-Research Center for Malignome, Metabolome and Microbiome, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, Faculty of Medicine, University of Tübingen, Tübingen, Germany.;Department Internal Medicine I, University Hospital Tübingen, Tübingen, Germany.
[46]
Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.;CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.;Center for Brain Research and Advancements in Neuroimmunology (BRAIN), Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[47]
Department of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, Switzerland.;Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
[48]
Center for Novel Therapeutics and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.;Division of Genomics and Precision Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
[49]
Core Facility for Histopathology and Digital Pathology, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.;Institute for Surgical Pathology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[50]
DKFZ-Bayer Immunotherapeutic Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[51]
Systems Immunology and Single-Cell Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
[52]
Center for Metabolic and Liver Disease, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.;Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
[53]
Werner Siemens Imaging Center (WSIC), Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.;Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.;M3-Research Center for Malignome, Metabolome and Microbiome, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, Faculty of Medicine, University of Tübingen, Tübingen, Germany.;Core Facility Metabolomics, Medical Faculty University of Tübingen, Tübingen, Germany.
[54]
Liver Cancer Translational Research Group, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.;Mount Sinai Liver Cancer Program, Divisions of Liver Diseases, Department of Hematology/Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
[55]
Chair of Nutrition and Immunology, Technische Universität München, Freising, Germany. dirk.haller@tum.de.;ZIEL Institute for Food and Health, Technische Universität München, Freising, Germany. dirk.haller@tum.de.
[56]
Center for Metabolic and Liver Disease, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. rkaufman@sbpdiscovery.org.
[57]
Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. m.heikenwaelder@dkfz-heidelberg.de.;Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany. m.heikenwaelder@dkfz-heidelberg.de.;M3-Research Center for Malignome, Metabolome and Microbiome, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, Faculty of Medicine, University of Tübingen, Tübingen, Germany. m.heikenwaelder@dkfz-heidelberg.de.;Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, University of Tübingen, Tübingen, Germany. m.heikenwaelder@dkfz-heidelberg.de.
[58]
医学主题词
肝肿瘤(Liver Neoplasms);动物(Animals);激活转录因子6(Activating Transcription Factor 6);癌, 肝细胞(Carcinoma, Hepatocellular);小鼠(Mice);人类(Humans);肝细胞(Hepatocytes);女(雌)性(Female);免疫学监视(Immunologic Surveillance);男(雄)性(Male);监测, 免疫学(Monitoring, Immunologic);糖酵解(Glycolysis);非折叠蛋白质应答(Unfolded Protein Response);细胞增殖(Cell Proliferation);免疫疗法(Immunotherapy)
DOI
10.1038/s41586-025-10036-8
PMID
41639449
发布时间
2026-05-29
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Nature
Nature
796-807页
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