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Functionalized osteogenic extracellular vesicles derived from BMP9-stimulated mesenchymal stem cells (MSCs) effectively induce bone regeneration.

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第一作者: Aohua,Li
第一单位: Ministry of Education Key Laboratory of Diagnostic Medicine, and Department of Clinical Biochemistry, School of Laboratory Diagnostic Medicine, Chongqing Medical University, Chongqing, 400016, China; Western Institute of Digital-Intelligent Medicine, Chongqing, 401329, China.
作者: Aohua,Li [1] ; Yi,Zhu [2] ; Saidur,Rahaman [3] ; Ailing,Hao [3] ; Yannian,Gou [3] ; Xiangyu,Dong [3] ; Han,Xiang [3] ; Jiajia,Li [3] ; Yiheng,Qiu [3] ; Caiyun,Zhang [3] ; Senjie,Xu [3] ; Jiamin,Zhong [4] ; Xingye,Wu [5] ; Yi,Shu [6] ; Chao,Yu [7] ; Yan,Peng [7] ; Yuting,Liang [8] ; Sarina,Zhao [9] ; Michelle,Xiang [9] ; Wonyong,Lee [9] ; Sofia,Bougioukli [9] ; Gregory,Schimizzi [9] ; Russell R,Reid [10] ; Xiaosong,Li [11] ; Tong-Chuan,He [12] ; Jiaming,Fan [13]
作者单位: Ministry of Education Key Laboratory of Diagnostic Medicine, and Department of Clinical Biochemistry, School of Laboratory Diagnostic Medicine, Chongqing Medical University, Chongqing, 400016, China; Western Institute of Digital-Intelligent Medicine, Chongqing, 401329, China. [1] Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Institute of Orthopaedics, Soochow University, Suzhou, 215006, China; Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA. [2] Ministry of Education Key Laboratory of Diagnostic Medicine, and Department of Clinical Biochemistry, School of Laboratory Diagnostic Medicine, Chongqing Medical University, Chongqing, 400016, China. [3] Ministry of Education Key Laboratory of Diagnostic Medicine, and Department of Clinical Biochemistry, School of Laboratory Diagnostic Medicine, Chongqing Medical University, Chongqing, 400016, China; Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA. [4] Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. [5] Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA; Stem Cell Biology and Therapy Laboratory of the Pediatric Research Institute, The National Clinical Research Center for Child Health and Disorders, And Ministry of Education Key Laboratory of Child Development and Disorders, The Children's Hospital of Chongqing Medical University, Chongqing, 400016, China. [6] Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA; Departments of Orthopaedic Surgery and Cardiology, The Affiliated University-town Hospital, Chongqing Medical University, Chongqing, 401331, China. [7] Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA; Center for Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. [8] Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA. [9] Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA; Laboratory of Craniofacial Biology and Development, Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medical Center, Chicago, IL, 60637, USA. [10] Ministry of Education Key Laboratory of Diagnostic Medicine, and Department of Clinical Biochemistry, School of Laboratory Diagnostic Medicine, Chongqing Medical University, Chongqing, 400016, China; Western Institute of Digital-Intelligent Medicine, Chongqing, 401329, China. Electronic address: lixiaosong@cqmu.edu.cn. [11] Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA; Laboratory of Craniofacial Biology and Development, Section of Plastic and Reconstructive Surgery, Department of Surgery, The University of Chicago Medical Center, Chicago, IL, 60637, USA. Electronic address: tche@uchicago.edu. [12] Ministry of Education Key Laboratory of Diagnostic Medicine, and Department of Clinical Biochemistry, School of Laboratory Diagnostic Medicine, Chongqing Medical University, Chongqing, 400016, China; Western Institute of Digital-Intelligent Medicine, Chongqing, 401329, China. Electronic address: fanjiaming1988@cqmu.edu.cn. [13]
DOI 10.1016/j.biomaterials.2026.124027
PMID 41643568
发布时间 2026-03-07
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