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Phase I Study Evaluating a Monoclonal Fc-Silenced SARS-CoV-2 Antibody in Patients With Moderate-to-Severe COVID-19.

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第一作者: Maddalena,Marconato
第一单位: Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland; Cluster of Excellence iFIT (EXC2180) "Image-Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.
作者单位: Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland; Cluster of Excellence iFIT (EXC2180) "Image-Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany. [1] Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) "Image-Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany. [2] Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany. [3] Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany. [4] Communal Non-Profit Enterprise "City clinical hospital" of Dnipro city council, Therapy Department, Dnipro State Medical University, Dnipro, Ukraine. [5] Municipal Non-Profit Enterprise of Regional Council Regional Clinical Infectious Hospital, Kharkiv, Ukraine. [6] CORAT Therapeutics GmbH, Braunschweig, Germany. [7] Department of Medical Biotechnology, Technische Universität Braunschweig, Braunschweig, Germany; Department of Biotechnology, Technische Universität Braunschweig, Braunschweig, Germany. [8] Department of Biotechnology, Technische Universität Braunschweig, Braunschweig, Germany. [9] Saarmetrics GmbH, Saarbrücken, Germany. [10] Saarmetrics GmbH, Saarbrücken, Germany; Clinical Pharmacy, Saarland University, Saarbrücken, Germany. [11] TUD Dresden University of Technology, Faculty of Medicine (and University Hospital), Carl Gustav Carus Department of Otorhinolaryngology Head and Neck Surgery, Dresden, Germany. [12] Cluster of Excellence iFIT (EXC2180) "Image-Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany; Departments of Clinical Pharmacology, and of Biochemistry and Pharmacy, University Tuebingen, Tuebingen, Germany; German Cancer Consortium (DKTK), partner site Tuebingen, a partnership between DKFZ and University Hospital Tuebingen, Tuebingen, Germany. [13] Universitätsklinikum Leipzig Medizinische Klinik II, Leipzig, Germany. [14] Department of Internal Medicine II, TUM University Hospital Rechts der Isar, Technical University of Munich, Munich, Germany. [15] Städtisches Klinikum Braunschweiq qGmbH Med. Klinik VII Klinik für Pneumoloqie und Beatmungsmedizin, Braunschweiq Germany. [16] Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany. [17] Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) "Image-Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tuebingen, a partnership between DKFZ and University Hospital Tuebingen, Tuebingen, Germany. [18] Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) "Image-Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tuebingen, a partnership between DKFZ and University Hospital Tuebingen, Tuebingen, Germany. [19] Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) "Image-Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany. Electronic address: jonas.heitmann@med.uni-tuebingen.de. [20]
DOI 10.1016/j.clinthera.2026.01.004
PMID 41654452
发布时间 2026-06-08
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