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Carriage of rare APOB variants predisposes to severe steatotic liver disease and hepatocellular carcinoma.

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第一作者: Matteo,Mureddu
第一单位: Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Policlinico, University of Milan, Milan, Italy.
作者单位: Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Policlinico, University of Milan, Milan, Italy. [1] Precision Medicine and Biological Resource Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy. [2] Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. [3] University of Pennsylvania Perelman School of Medicine, Pennsylvania, United States of America. [4] Scientific Direction, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy. [5] Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. [6] VA Salt Lake City Health Care System, Salt Lake City, United States of America. [7] VA Palo Alto Health Care System & Cardiovascular Medicine, Stanford University School of Medicine, Stanford, United States of America. [8] Neurology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy. [9] Liver Transplant Unit, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. [10] Precision Medicine and Biological Resource Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. [11] Hepatology, University of Padua, Padua, Italy. [12] Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy. [13] Gastroenterology and Endoscopy, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy. [14] Gastroenterology and Hepatology, PROMISE, University of Palermo, Palermo, Italy. [15] Department of Internal Medicine, Fondazione Policlinico A. Gemelli, Università Cattolica di Roma, Rome, Italy. [16] Clinical Medicine and Hepatology Unit, Department of Internal Medicine and, Campus Bio-Medico University, Rome, Italy. [17] Department of Medical Sciences, Division of Gastro-Hepatology, A.O. Città della Salute e della Scienza di Torino, Università di Torino, Turin, Italy. [18] Medical Unit Endocrinology, Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden. [19] RWTH University of Aachen, Aachen, Germany. [20]
DOI 10.1172/JCI201762
PMID 41665936
发布时间 2026-02-10
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The Journal of clinical investigation

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