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Tim1 Deficiency Mediates Gestational Hyperglycemia-Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction.

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第一作者： Junsen,She

第一单位： Center for Reproductive Medicine, International Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.;Women's Hospital, Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University School of Medicine, Hangzhou, China.

作者： Junsen,She ^[1] ; Rui,Liu ^[1] ; Chen,Fang ^[2] ; Shuyu,Zhang ^[3] ; Yizhi,Hu ^[2] ; Fei,Guo ^[4] ; Yuhang,Long ^[4] ; Mengzhen,Ding ^[1] ; Haiyan,Wu ^[2] ; Bokang,Zhou ^[4] ; Zexin,Yang ^[4] ; Ying,Jiang ^[2] ; Jianzhong,Sheng ^[5] ; Ling,Gao ^[4] ; Hefeng,Huang ^[5]

作者单位： Center for Reproductive Medicine, International Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.;Women's Hospital, Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University School of Medicine, Hangzhou, China. ^[1] Women's Hospital, Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University School of Medicine, Hangzhou, China. ^[2] The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ^[3] Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China. ^[4] Center for Reproductive Medicine, International Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.;Women's Hospital, Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University School of Medicine, Hangzhou, China.;Research Units of Embryo Original Diseases, Chinese Academy of Medical Sciences, Shanghai, China. ^[5]

关键词 fetal growth restriction gestational hyperglycemia oxidative stress syncytiotrophoblast

医学主题词女(雌)性(Female);妊娠(Pregnancy);胎儿生长迟缓(Fetal Growth Retardation);滋养层(Trophoblasts);动物(Animals);小鼠(Mice);高血糖症(Hyperglycemia);胎盘(Placenta);小鼠, 基因敲除(Mice, Knockout);人类(Humans);疾病模型, 动物(Disease Models, Animal);小鼠, 近交C57BL(Mice, Inbred C57BL);糖尿病, 妊娠(Diabetes, Gestational)

DOI 10.1002/advs.202508686

PMID 41669822

发布时间 2026-04-12

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2026年13卷20期

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Tim1 Deficiency Mediates Gestational Hyperglycemia-Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Tim1 Deficiency Mediates Gestational Hyperglycemia-Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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