首页> Science advances> VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.

VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.

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第一作者： Leonie M,Heger

第一单位： Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany.;Graduate School of Systemic Neurosciences (GSN), LMU Munich, Munich, Germany.

作者： Leonie M,Heger ^[1] ; Francesco,Gubinelli ^[2] ; Andreas J,Huber ^[1] ; Aida,Cardona-Alberich ^[2] ; Matteo,Rovere ^[1] ; Ulf,Matti ^[3] ; Stephan A,Müller ^[4] ; Sankarshana R,Nagaraja ^[5] ; Lena,Jaschkowitz ^[2] ; Martina,Schifferer ^[6] ; Wolfgang,Wurst ^[7] ; Stefan F,Lichtenthaler ^[8] ; Christian,Behrends ^[5] ; Sivakumar,Sambandan ^[9] ; Lena F,Burbulla ^[10]

作者单位： Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany.;Graduate School of Systemic Neurosciences (GSN), LMU Munich, Munich, Germany. ^[1] Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany. ^[2] Abberior Instruments GmbH, Göttingen, Germany. ^[3] Neuroproteomics, School of Medicine and Health, TUM University Hospital, Technical University of Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. ^[4] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;Faculty of Medicine, LMU Munich, Munich, Germany. ^[5] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. ^[6] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;Helmholtz Munich, Institute of Developmental Genetics, Technical University Munich, Institute of Developmental Genetics, Munich, Germany. ^[7] Neuroproteomics, School of Medicine and Health, TUM University Hospital, Technical University of Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. ^[8] Laboratory of Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.;Synaptic Metal Ion Dynamics and Signaling, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. ^[9] Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. ^[10]

医学主题词囊泡单胺转运蛋白质类(Vesicular Monoamine Transport Proteins);多巴胺(Dopamine);帕金森病(Parkinson Disease);人类(Humans);α突触核蛋白(alpha-Synuclein);氧化还原(Oxidation-Reduction);动物(Animals);突触小泡(Synaptic Vesicles);小鼠(Mice);腺苷三磷酸(Adenosine Triphosphate);诱导多能干细胞(Induced Pluripotent Stem Cells);中脑(Mesencephalon)

DOI 10.1126/sciadv.adz5645

PMID 41671379

发布时间 2026-02-14

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VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.

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VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.

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