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Ablation of prostaglandin E<sub>2</sub> signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours.

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第一作者: Janina,Dörr
第一单位: Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
作者单位: Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany. [1] Institute of Molecular Immunology, TUM University Hospital, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.;Servier Deutschland, Munich, Germany. [2] Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA. [3] Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.;Department of Medicine II, LMU University Hospital, Munich, Germany.;Gene Center, Department of Biochemistry, LMU Munich, Munich, Germany. [4] Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.;Department of Medicine III, LMU University Hospital, LMU, Munich, Germany. [5] Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. [6] Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. [7] Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.;Department of Medicine III, LMU University Hospital, LMU, Munich, Germany.;German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, LMU, Munich, Germany. [8] Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.;German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, LMU, Munich, Germany. [9] Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.;German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, LMU, Munich, Germany.;Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Zentrum München-German Research Center for Environmental Health Neuherberg, Munich, Germany. [10] Institute of Molecular Immunology, TUM University Hospital, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.;M3 Research Center, University Hospital Tübingen, University of Tübingen, Tübingen, Germany.;Department of Experimental Immunology, Institute of Immunology, University of Tübingen, Tübingen, Germany. [11] Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany. Sebastian.kobold@med.uni-muenchen.de.;German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, LMU, Munich, Germany. Sebastian.kobold@med.uni-muenchen.de.;Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Zentrum München-German Research Center for Environmental Health Neuherberg, Munich, Germany. Sebastian.kobold@med.uni-muenchen.de.;German Center for Lung Research (DZL), Partner Site Munich, Munich, Germany. Sebastian.kobold@med.uni-muenchen.de. [12]
DOI 10.1038/s41551-025-01610-6
PMID 41673138
发布时间 2026-02-11
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