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Speech Impairment in Early Parkinson's Disease Is Associated with Nigrostriatal Dopaminergic Dysfunction.

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第一作者： Sotirios,Polychronis

第一单位： Department of Speech & Language Therapy, School of Health Sciences, University of Ioannina, 45500 Ioannina, Greece.

作者： Sotirios,Polychronis ^[1] ; Grigorios,Nasios ^[1] ; Efthimios,Dardiotis ^[2] ; Rayo,Akande ^[3] ; Gennaro,Pagano ^[3]

作者单位： Department of Speech & Language Therapy, School of Health Sciences, University of Ioannina, 45500 Ioannina, Greece. ^[1] Department of Medicine, University of Thessaly, 41500 Larissa, Greece.;Department of Neurology, University Hospital of Larissa, 41110 Larissa, Greece. ^[2] F. Hoffmann-La Roche Ltd., Neuroscience and Rare Diseases, Roche Pharma Research and Early Development, 4058 Basel, Switzerland. ^[3]

关键词 Parkinson’s disease [123I]FP-CIT basal ganglia cerebrospinal fluid biomarkers dopaminergic deficit hypokinetic dysarthria levodopa motor impairment putamen speech difficulties

DOI 10.3390/jcm15031006

PMID 41682687

发布时间 2026-02-16

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Journal of clinical medicine

2026年15卷3期

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Journal of clinical medicine

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Speech Impairment in Early Parkinson's Disease Is Associated with Nigrostriatal Dopaminergic Dysfunction.

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Speech Impairment in Early Parkinson's Disease Is Associated with Nigrostriatal Dopaminergic Dysfunction.

Journal of clinical medicine

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