首页> Bone> NSUN6-mediated m5C RNA methylation aggravate osteosarcoma progression through promoting PKP2 mRNA stability and expression.

NSUN6-mediated m5C RNA methylation aggravate osteosarcoma progression through promoting PKP2 mRNA stability and expression.

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第一作者： Chunyan,Zhao

第一单位： Department of Medical Laboratory, Yibin Hospital of Children's Hospital Affiliated to Chongqing Medical University, Yibin, Sichuan, 644000, China.

作者： Chunyan,Zhao ^[1] ; Yun,Tang ^[2] ; Yongpeng,He ^[2] ; Fagen,Zhang ^[1] ; Wenqian,Li ^[1] ; Xiaochun,Chen ^[3] ; Zhengyang,Yu ^[4] ; Kaiwen,Fu ^[5]

作者单位： Department of Medical Laboratory, Yibin Hospital of Children's Hospital Affiliated to Chongqing Medical University, Yibin, Sichuan, 644000, China. ^[1] Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, 400030, China. ^[2] Department of Oncology, the First People's Hospital of Yibin, Yibin, Sichuan Province, 644000, China. ^[3] Department of Foot and Ankle Surgery, Chongqing Orthopedic Hospital of Traditional Chinese Medicine & The People's Hospital of Chongqing Yuzhong District & Chongqing Institute of Orthopedics of Traditional Chinese Medicine, Chongqing, 400039, China. Electronic address: yuzhengyang0629@163.com. ^[4] Chongqing Key Laboratory for the Mechanism and Intervention of Cancer Metastasis, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, 400030, China. Electronic address: fukaiwen1987@163.com. ^[5]

关键词 Ferroptosis NOP2/Sun RNA methyltransferase 6 Osteosarcoma Oxidative stress Plakophilin 2 m5C methylation modification