换一批MST1 promotes microglial pyroptosis and neuroinflammation in alzheimer's disease by regulating the novel DPP8/NLRP1/Caspase-1/GSDMD-N axis.
第一作者：
Dongqing,Cui
第一单位：
Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Provincial Key Laboratory of Mitochondrial Medicine and Rare Diseases, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
作者：
医学主题词
动物(Animals);阿尔茨海默病(Alzheimer Disease);小鼠(Mice);小神经胶质细胞(Microglia);人类(Humans);小鼠, 转基因(Mice, Transgenic);半胱氨酸天冬氨酸蛋白酶1(Caspase 1);男(雄)性(Male);信号传导(Signal Transduction);衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);小鼠, 近交C57BL(Mice, Inbred C57BL);女(雌)性(Female);凋亡调节蛋白质类(Apoptosis Regulatory Proteins);磷酸结合蛋白质类(Phosphate-Binding Proteins)
DOI
10.1186/s12974-026-03732-3
PMID
41689046
发布时间
2026-03-23
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