首页> European journal of medicinal chemistry> N-terphenylpicolinamide derivatives designed to target PD-L1 increase activation and proliferation of T cells, and their cytotoxic properties toward cancer cells.

N-terphenylpicolinamide derivatives designed to target PD-L1 increase activation and proliferation of T cells, and their cytotoxic properties toward cancer cells.

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第一作者： Damian,Muszak

第一单位： Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, Krakow, 30-387, Poland. Electronic address: damian.muszak@uj.edu.pl.

作者： Damian,Muszak ^[1] ; Justyna,Kocik-Krol ^[2] ; Julia,Zaber ^[3] ; Oskar,Kruc ^[3] ; Urszula,Palej ^[2] ; Karolina,Fijolkowska ^[2] ; Agnieszka,Maslanka ^[3] ; Katarzyna,Magiera-Mularz ^[2] ; Jacek,Plewka ^[2] ; Malgorzata,Stec ^[4] ; Marcin,Surmiak ^[5] ; Malgorzata,Szafarz ^[6] ; Maciej,Siedlar ^[4] ; Bogdan,Musielak ^[2] ; Radoslaw,Kitel ^[2] ; Elzbieta,Wyska ^[6] ; Lukasz,Skalniak ^[2] ; Ewa,Surmiak ^[7]

作者单位： Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, Krakow, 30-387, Poland. Electronic address: damian.muszak@uj.edu.pl. ^[1] Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, Krakow, 30-387, Poland. ^[2] Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, Krakow, 30-387, Poland; Jagiellonian University, Doctoral School of Exact and Natural Sciences, prof. S. Lojasiewicza 11, Krakow, 30-348, Poland. ^[3] Jagiellonian University Medical College, Institute of Pediatrics, Department of Clinical Immunology, Wielicka 265, Krakow, 30-663, Poland. ^[4] Jagiellonian University Medical College, Bioengineering and Cell Imaging Laboratory, Center for the Development of Therapies for Civilization and Age-Related Diseases, Skawińska 8, Krakow, 31-066, Poland. ^[5] Jagiellonian University Medical College, Faculty of Pharmacy, Department of Pharmacokinetics and Physical Pharmacy, Medyczna 9, Krakow, 30-688, Poland. ^[6] Jagiellonian University, Faculty of Chemistry, Department of Organic Chemistry, Gronostajowa 2, Krakow, 30-387, Poland. Electronic address: ewa.surmiak@uj.edu.pl. ^[7]

关键词 Cancer cells elimination In vitro PD-L1 Small molecule blocker T cell activation