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Phenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese Adults.

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第一作者： Baihan,Wang

第一单位： Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

作者： Baihan,Wang ^[1] ; Sam,Morris ^[1] ; Hannah,Fry ^[1] ; Andri,Iona ^[1] ; Jonathan,Clarke ^[1] ; Kuang,Lin ^[1] ; Igor,Pupko ^[2] ; Christiana,Kartsonaki ^[1] ; Derrick A,Bennett ^[1] ; Yiping,Chen ^[1] ; Huaidong,Du ^[1] ; Ling,Yang ^[1] ; Daniel,Avery ^[1] ; Dan,Schmidt-Valle ^[1] ; Shixian,Feng ^[3] ; Dianjianyi,Sun ^[4] ; Canqing,Yu ^[4] ; Jun,Lv ^[4] ; Pei,Pei ^[5] ; Junshi,Chen ^[6] ; Karoline,Kuchenbaecker ^[2] ; Naomi R,Wray ^[7] ; Liming,Li ^[4] ; Robin G,Walters ^[1] ; Zhengming,Chen ^[1] ; Iona Y,Millwood ^[1] ; China Kadoorie Biobank Collaborative Group

作者单位： Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. ^[1] Division of Psychiatry, University College London, London, United Kingdom. ^[2] Non-Communicable Diseases Prevention and Control Department, Henan Centre for Disease Control and Prevention, Zhengzhou, China. ^[3] Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.;Peking University Center for Public Health and Epidemic Preparedness and Response, Peking University, Beijing, China.;Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China. ^[4] Peking University Center for Public Health and Epidemic Preparedness and Response, Peking University, Beijing, China. ^[5] China National Center for Food Safety Risk Assessment, Beijing, China. ^[6] Department of Psychiatry, University of Oxford, Oxford, United Kingdom.;Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. ^[7]

关键词 Causal inference Cross-population comparison Depression Phenome-wide association study Polygenic score Schizophrenia

DOI 10.1016/j.bpsgos.2025.100681

PMID 41704843

发布时间 2026-02-18

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Biological psychiatry global open science

2026年6卷2期

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Biological psychiatry global open science

2026年6卷2期

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Phenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese Adults.

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Phenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese Adults.

Biological psychiatry global open science

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