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Proline, a privileged fragment in drug design: advances and future perspectives.

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第一作者： Ting-Ting,Li

第一单位： School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China.

作者： Ting-Ting,Li ^[1] ; Li-Rong,Liu ^[1] ; Gong-Hui,Ge ^[1] ; Shuai,Guo ^[1] ; Xu,Zhang ^[1] ; Xian-Feng,Zhou ^[1] ; Jia-Yao,Liu ^[1] ; Jing-Wei,Liang ^[2] ; Fan-Hao,Meng ^[3] ; Ting-Jian,Zhang ^[4]

作者单位： School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China. ^[1] School of Pharmacy, Hainan Medical University, Haikou, Hainan, 571199, China; Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, 571199, China. Electronic address: jwliang@muhn.edu.cn. ^[2] School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China. Electronic address: fhmeng@cmu.edu.cn. ^[3] School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China. Electronic address: tjzhang@cmu.edu.cn. ^[4]

关键词 Advances Drug design Perspectives Privileged fragment Proline

医学主题词脯氨酸(Proline);药物设计(Drug Design);人类(Humans);分子结构(Molecular Structure);小分子化合物库(Small Molecule Libraries)

DOI 10.1016/j.ejmech.2026.118685

PMID 41719804

发布时间 2026-03-12

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