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Herpes simplex virus-1 induces complement-mediated microglial phagocytosis of synapses in murine primary brain cultures and tissues.

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第一作者： Mariya Timotey,Miteva

第一单位： Institute of Translational Pharmacology, Council of National Research, Rome, Italy.;Department of Public Health and Infectious Diseases, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.

作者： Mariya Timotey,Miteva ^[1] ; Virginia,Protto ^[2] ; Francesco,Zanzi ^[1] ; Francesco,Pastore ^[3] ; Chiara,Simone ^[3] ; Cristian,Ripoli ^[3] ; Maria Elena,Marcocci ^[4] ; Roberto,Piacentini ^[3] ; Claudio,Grassi ^[3] ; Anna Teresa,Palamara ^[5] ; Giovanna,De Chiara ^[6]

作者单位： Institute of Translational Pharmacology, Council of National Research, Rome, Italy.;Department of Public Health and Infectious Diseases, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy. ^[1] Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy. ^[2] Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.;Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. ^[3] Department of Public Health and Infectious Diseases, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy. ^[4] Department of Public Health and Infectious Diseases, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.;Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy. ^[5] Institute of Translational Pharmacology, Council of National Research, Rome, Italy. giovanna.dechiara@ift.cnr.it. ^[6]

关键词 Alzheimer’s disease Complement proteins HHV-1 HSV-1 Herpes simplex virus Microglial synaptic pruning Neurodegeneration

DOI 10.1186/s12964-026-02745-y

PMID 41721402

发布时间 2026-06-25

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